Cimzia and Reglan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cimzia (certolizumab pegol) and Reglan (metoclopramide hydrochloride). Common drug interactions include pallor among females and intestinal obstruction among males.

The phase IV clinical study analyzes what interactions people have when they take Cimzia and Reglan. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Cimzia?

Cimzia has active ingredients of certolizumab pegol. It is often used in rheumatoid arthritis. eHealthMe is studying from 106,745 Cimzia users. Check the latest studies of Cimzia.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

65 people who take Cimzia and Reglan together, and have interactions are studied.

What are the common drug interactions of Cimzia and Reglan, by gender? *:

female:

Pallor
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pleurisy viral (inflammation of the pleurae, which causes pain when breathing by viral infection)
Pneumonia respiratory syncytial viral (respiratory syncytial virus (rsv) is a very common virus that leads to mild, cold-like symptoms in adults and older healthy children)
Pregnancy
Pruritus generalised (generalized itching)
Upper limb fracture
Upper respiratory tract infection
Vulvovaginal injury
Anal abscess

male:

Intestinal obstruction
Urinary tract infection
Acute respiratory distress syndrome
Dehydration (dryness resulting from the removal of water)
Dental caries
Drug ineffective
Faecal incontinence (a lack of control over passing stool)
Failure to thrive (inadequate weight gain and physical growth in children)
Loose tooth
Nail disorder (disease of nail)

What are the common drug interactions of Cimzia and Reglan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Gastric ulcer haemorrhage (bleeding ulcer of stomach)
Gastrointestinal hypomotility (less activity of the intestinal tract)
International normalised ratio increased
Pulmonary embolism (blockage of the main artery of the lung)
Blood pressure increased
Breast pain
Burning sensation
Diarrhoea
Fatigue (feeling of tiredness)
Infection

30-39:

Dehydration (dryness resulting from the removal of water)
Urinary tract infection
Acute respiratory distress syndrome
Anal abscess
Drug ineffective
Faecal incontinence (a lack of control over passing stool)
Failure to thrive (inadequate weight gain and physical growth in children)
Impaired gastric emptying
Insomnia (sleeplessness)
Muscle spasms (muscle contraction)

40-49:

Purulent discharge (discharge that contains pus)
Rash
Swelling face
Vagus nerve disorder
Abdominal pain
Cellulitis (infection under the skin)
Chills (felling of cold)
Pain
Rectal haemorrhage (bleeding from anus)
Vulval abscess

50-59:

Urinary tract infection
Fatigue (feeling of tiredness)
Fall
Humerus fracture (injury to the upper arm bone)
Intestinal obstruction
Vomiting
Alopecia (absence of hair from areas of the body)
Ascites (accumulation of fluid in the abdominal cavity)
Blood glucose increased
Candidiasis (candidiasis or thrush is a fungal infection)

60+:

Urinary tract infection
Renal failure acute (rapid kidney dysfunction)
Dysphagia (a condition in which swallowing is difficult or painful)
Faecaloma (hard mass of fecal matter)
Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
Hydronephrosis (water inside the kidney)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Joint swelling
Kidney transplant rejection
Left ventricular failure (left ventricle fails to contract forcefully)

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 28 people, 43.08%
Pain: 10 people, 15.38%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 6 people, 9.23%
Nausea (feeling of having an urge to vomit): 4 people, 6.15%
High Blood Pressure: 4 people, 6.15%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 6.15%

* Approximation only. Some reports may have incomplete information.

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