Clarithromycin and Depakote drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clarithromycin (clarithromycin) and Depakote (divalproex sodium). Common drug interactions include myopericarditis among females and renal failure acute among males.

The phase IV clinical study analyzes what interactions people have when they take Clarithromycin and Depakote. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Clarithromycin?

Clarithromycin has active ingredients of clarithromycin. It is often used in sinusitis. eHealthMe is studying from 45,044 Clarithromycin users. Check the latest studies of Clarithromycin.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

47 people who take Clarithromycin and Depakote together, and have interactions are studied.

Clarithromycin and Depakote drug interactions.

What are the common drug interactions of Clarithromycin and Depakote, by gender? *:

female:

Myopericarditis (disease caused by inflammation of the myocardium (muscle of the heart wall) and/or the pericardium)
Polyuria (production of too much dilute urine)
Vomiting
Abdominal distension
Abdominal pain
Anger
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anorectal disorder
Anxiety
Aortic valve incompetence

male:

Renal failure acute (rapid kidney dysfunction)
Hypotension (abnormally low blood pressure)
Loss of consciousness
Pain
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Sepsis (a severe blood infection that can lead to organ failure and death)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Ankle fracture
Blood creatinine increased
Chronic kidney disease

What are the common drug interactions of Clarithromycin and Depakote, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
Hypersensitivity
Oedema peripheral (superficial swelling)
Rash

10-19:

Hepatic adenoma (benign liver tumour)

20-29:

Chest pain
Nausea (feeling of having an urge to vomit)
Cardiac enzymes increased
Myocarditis (inflammation of heart muscle myocardium)
Myopericarditis (disease caused by inflammation of the myocardium (muscle of the heart wall) and/or the pericardium)
Vomiting
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Faecal incontinence (a lack of control over passing stool)
Loss of consciousness
Urinary incontinence (inability to control the flow of urine and involuntary urination)

30-39:

Pancreatitis (inflammation of pancreas)
Anger
Depression
Insomnia (sleeplessness)
Mania (a state of abnormally elevated or irritable mood)
Mood swings (an extreme or rapid change in mood)
Organising pneumonia (pathologically by the presence in the distal air spaces of buds of granulation tissue)
Road traffic accident
Sleep disorder

40-49:

Faecal incontinence (a lack of control over passing stool)
Gastric infection (infection of stomach)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gastrointestinal infection (infection of stomach and intestine)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Infusion site bruising
Injection site discharge
Injection site pain

50-59:

Abdominal distension
Abdominal pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anorectal disorder
Anxiety
Blood glucose increased
Blood thyroid stimulating hormone increased
Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)
Chest injury
Chest pain

60+:

Hypotension (abnormally low blood pressure)
Drug administration error
General physical health deterioration (weak health status)
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Stress
Tachyphrenia (abnormally rapid mental activity)
Thrombocytopenia (decrease of platelets in blood)
Blood creatinine increased
Dysphagia (a condition in which swallowing is difficult or painful)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 8.51%
Pain: 3 people, 6.38%
Nasopharyngitis (inflammation of the nasopharynx): 3 people, 6.38%
Migraine (headache): 3 people, 6.38%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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