Clarithromycin and Donepezil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clarithromycin (clarithromycin) and Donepezil (donepezil hydrochloride). Common drug interactions include oedema among females and hallucination among males.

The phase IV clinical study analyzes what interactions people have when they take Clarithromycin and Donepezil. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Clarithromycin?

Clarithromycin has active ingredients of clarithromycin. It is often used in sinusitis. eHealthMe is studying from 45,044 Clarithromycin users. Check the latest studies of Clarithromycin.

What is Donepezil?

Donepezil has active ingredients of donepezil hydrochloride. It is often used in dementia. eHealthMe is studying from 24,564 Donepezil users. Check the latest studies of Donepezil.

On Jul, 27, 2026

98 people who take Clarithromycin and Donepezil together, and have interactions are studied.

Clarithromycin and Donepezil drug interactions.

What are the common drug interactions of Clarithromycin and Donepezil, by gender? *:

female:

Oedema (fluid collection in tissue)
Scab (a hard coating on the skin formed during the wound healing)
Secretion discharge
Skin exfoliation (removal of the oldest dead skin cells)
Troponin increased
White blood cell count increased
Drug level increased
Blood pressure decreased
Bradycardia (abnormally slow heart action)
Death

male:

Hallucination (an experience involving the perception of something not present)
Confusional state
Drug ineffective
Dyskinesia (abnormality or impairment of voluntary movement)
Lung disorder (lung disease)
Blood pressure decreased
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Blood pressure increased
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Glaucoma (increased fluid pressure in the eye with vision loss)

What are the common drug interactions of Clarithromycin and Donepezil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Gingival hypertrophy (overgrowth of gums)
Hypoxia (low oxygen in tissues)
Hypoxic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
Incision site complication
Pallor
Speech disorder
Weight decreased
Bradycardia (abnormally slow heart action)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)

50-59:

n/a

60+:

General physical health deterioration (weak health status)
Chest pain
Oedema (fluid collection in tissue)
Tremor (trembling or shaking movements in one or more parts of your body)
Asthenia (weakness)
Cardiac failure
Confusional state
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Left ventricular dysfunction
Scab (a hard coating on the skin formed during the wound healing)

What are the existing conditions these people have? *

Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 18 people, 18.37%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 16 people, 16.33%
Parkinson's Disease: 14 people, 14.29%
Memory Loss: 13 people, 13.27%
Hallucinations (sensations that appear real but are created by your mind): 13 people, 13.27%
Urticaria (rash of round, red welts on the skin that itch intensely): 11 people, 11.22%
Hypotension (abnormally low blood pressure): 11 people, 11.22%
Delusion (a false belief or opinion): 10 people, 10.20%
Varices Oesophageal (enlarged and swollen veins at the bottom of the oesophagus, near the stomach): 9 people, 9.18%
High Blood Cholesterol: 9 people, 9.18%

* Approximation only. Some reports may have incomplete information.

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