Clarithromycin and Mefenamic acid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clarithromycin (clarithromycin) and Mefenamic acid (mefenamic acid). Common drug interactions include autoimmune disorder among females and rash among males.

The phase IV clinical study analyzes what interactions people have when they take Clarithromycin and Mefenamic acid. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Clarithromycin?

Clarithromycin has active ingredients of clarithromycin. It is often used in sinusitis. eHealthMe is studying from 45,044 Clarithromycin users. Check the latest studies of Clarithromycin.

What is Mefenamic acid?

Mefenamic acid has active ingredients of mefenamic acid. It is often used in painful menstrual periods. eHealthMe is studying from 4,844 Mefenamic acid users. Check the latest studies of Mefenamic acid.

On Aug, 09, 2026

72 people who take Clarithromycin and Mefenamic acid together, and have interactions are studied.

Clarithromycin and Mefenamic acid drug interactions.

What are the common drug interactions of Clarithromycin and Mefenamic Acid, by gender? *:

female:

Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Blood alkaline phosphatase nos increased
Blood lactate dehydrogenase increased
Bone swelling
Breast cancer
C-reactive protein increased
Cardiomyopathy (weakening of the heart muscle)
Chronic hepatic failure (long lasting liver failure)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)

male:

Rash
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Atrial tachycardia (rhythm disturbance that arises in the atria)
Blood creatinine increased
Blood urine
Chronic kidney disease
Complement factor c3 decreased
Complement factor c4 decreased
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Protein urine present

What are the common drug interactions of Clarithromycin and Mefenamic Acid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Cardiomyopathy (weakening of the heart muscle)
Myocarditis (inflammation of heart muscle myocardium)

10-19:

Oedema (fluid collection in tissue)
Pruritus (severe itching of the skin)
Rash erythematous (redness of the skin)
Abdominal pain upper
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Diabetes insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function)
Liver transplant
Nausea (feeling of having an urge to vomit)

20-29:

n/a

30-39:

Haemorrhagic stroke (stroke caused by the rupture of a blood vessel in the brain)
Hospitalisation
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Chapped lips (cracking, fissuring, and peeling of the skin f lip)
Malaise (a feeling of general discomfort or uneasiness)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Post procedural complication
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Abdominal discomfort

40-49:

Asthenia (weakness)
Cough
Deafness
Dizziness
Dysgeusia (disorder of the sense of taste)
Malaise (a feeling of general discomfort or uneasiness)
Mood swings (an extreme or rapid change in mood)
Tinnitus (a ringing in the ears)
Vertigo
Wheezing (a high-pitched whistling sound made while you breath)

50-59:

Osteomyelitis (infection of bone)
Osteonecrosis of jaw (death of bone of jaw)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Pyrexia (fever)
Arthralgia (joint pain)
Myalgia (muscle pain)
Rash
Renal failure acute (rapid kidney dysfunction)
Vasculitis (inflammation of a blood vessel or blood vessels)
Chills (felling of cold)

60+:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Loss of consciousness
Memory impairment
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pruritus (severe itching of the skin)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Stress at work

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 13.89%
Fever: 8 people, 11.11%
Osteoporosis (bones weak and more likely to break): 6 people, 8.33%
Urticaria (rash of round, red welts on the skin that itch intensely): 4 people, 5.56%
Lower Respiratory Tract Infection: 4 people, 5.56%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 4 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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