Clarithromycin and Sandimmune drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clarithromycin (clarithromycin) and Sandimmune (cyclosporine). Common drug interactions include encephalopathy among females and somnolence among males.

The phase IV clinical study analyzes what interactions people have when they take Clarithromycin and Sandimmune. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Clarithromycin?

Clarithromycin has active ingredients of clarithromycin. It is often used in sinusitis. eHealthMe is studying from 45,044 Clarithromycin users. Check the latest studies of Clarithromycin.

What is Sandimmune?

Sandimmune has active ingredients of cyclosporine. eHealthMe is studying from 6,694 Sandimmune users. Check the latest studies of Sandimmune.

On Aug, 10, 2026

21 people who take Clarithromycin and Sandimmune together, and have interactions are studied.

Clarithromycin and Sandimmune drug interactions.

What are the common drug interactions of Clarithromycin and Sandimmune, by gender? *:

female:

Encephalopathy (functioning of the brain is affected by some agent or condition)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Headache (pain in head)
Muscle weakness (a lack of muscle strength)
Nausea (feeling of having an urge to vomit)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Renal failure (kidney dysfunction)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)

male:

Somnolence (a state of near-sleep, a strong desire for sleep)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cough
Diarrhoea
Epistaxis (bleed from the nose)
Headache (pain in head)
Mydriasis (a dilation of the pupil)
Nausea (feeling of having an urge to vomit)
Oxygen saturation decreased

What are the common drug interactions of Clarithromycin and Sandimmune, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Hepatic steatosis (fatty liver disease)
Immunosuppressant drug level increased
Neurogenic shock (insufficient blood flow throughout the body due to injury in spinal cord)
Pyrexia (fever)
Renal tubular necrosis (death of kidney tubules)
Tinnitus (a ringing in the ears)
Visceral congestion (blocking of internal organs of the body)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Cytomegalovirus infection
Fatigue (feeling of tiredness)

10-19:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Deafness
Encephalopathy (functioning of the brain is affected by some agent or condition)
Muscle contractions involuntary (uncontrolled muscle contraction)
Muscle twitching
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Petit mal epilepsy (absence seizure)
Tremor (trembling or shaking movements in one or more parts of your body)

20-29:

n/a

30-39:

Blood pressure increased
Cerebral oedema (swelling of brain)
Communication disorder (speech and language disorder)
Cytomegalovirus infection
Encephalopathy (functioning of the brain is affected by some agent or condition)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

40-49:

Renal impairment (severely reduced kidney function)
Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
Blood creatinine increased
Chest discomfort
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cytomegalovirus test positive
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Eye infection
Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)

50-59:

Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Multi-organ failure (multisystem organ failure)
Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Drug therapeutic incompatibility
Immunosuppressant drug level increased
Muscle weakness (a lack of muscle strength)
Myalgia (muscle pain)
Renal failure (kidney dysfunction)
Tonic seizures (all the muscles to suddenly become stiff)
Upper respiratory tract infection
Weakness

What are the existing conditions these people have? *

Obliterative Bronchiolitis (bronchiolar inflammation): 2 people, 9.52%
Eye Infection: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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