Claritin-d and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Claritin-d (loratadine; pseudoephedrine sulfate) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include insomnia among females and uveitis among males.

The phase IV clinical study analyzes what interactions people have when they take Claritin-d and Excedrin. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Claritin-d?

Claritin-d has active ingredients of loratadine; pseudoephedrine sulfate. It is often used in allergies. eHealthMe is studying from 7,055 Claritin-d users. Check the latest studies of Claritin-d.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

On Jul, 05, 2026

22 people who take Claritin-d and Excedrin together, and have interactions are studied.

Claritin-d and Excedrin drug interactions.

What are the common drug interactions of Claritin-D and Excedrin, by gender? *:

female:

Insomnia (sleeplessness)
Muscle spasms (muscle contraction)
Rash
Therapeutic response unexpected
Abnormal dreams
Acute sinusitis
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthralgia (joint pain)
Blindness transient (sudden loss of vision)

male:

Uveitis (inflammation of the uvea)
Sinusitis (inflammation of sinus)

What are the common drug interactions of Claritin-D and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blindness transient (sudden loss of vision)
Blood disorder
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Emotional distress
General physical health deterioration (weak health status)
Injury
Intracranial venous sinus thrombosis (presence of thrombosis (a blood clot) in the dural venous sinuses, which drain blood from the brain)

30-39:

Panic attack
Sexual abuse
Sinusitis (inflammation of sinus)

40-49:

Nausea (feeling of having an urge to vomit)
Anxiety
Cardiac failure
Death
Depression
Diarrhoea
Fatigue (feeling of tiredness)
Hereditary angioedema (recurrent episodes of severe swelling)
Hypoxia (low oxygen in tissues)
Iron deficiency anaemia

50-59:

Uveitis (inflammation of the uvea)
Dizziness
Nausea (feeling of having an urge to vomit)
Abnormal dreams
Anxiety
Heart rate increased
Hyperacusis (disorder in loudness perception)
Insomnia (sleeplessness)
Muscle spasms (muscle contraction)
Paranasal sinus discomfort

60+:

Acute sinusitis
Chills (felling of cold)
Meningitis bacterial (bacterial inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Muscular weakness (muscle weakness)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Otitis media acute (rapid inflammation of the middle ear)
Rash
Rash erythematous (redness of the skin)
Rash pruritic (redness with itching)

What are the existing conditions these people have? *

Hypersensitivity: 5 people, 22.73%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 22.73%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 18.18%
Depression: 4 people, 18.18%
High Blood Pressure: 4 people, 18.18%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 13.64%
Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 3 people, 13.64%
Erection Problems: 3 people, 13.64%
Gastritis (inflammation of stomach): 3 people, 13.64%
High Blood Cholesterol: 3 people, 13.64%

* Approximation only. Some reports may have incomplete information.

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