Claritin and Epiduo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Claritin (loratadine) and Epiduo (adapalene; benzoyl peroxide). Common drug interactions include skin exfoliation among females and injection site reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Claritin and Epiduo. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Claritin?

Claritin has active ingredients of loratadine. It is often used in allergies. eHealthMe is studying from 77,315 Claritin users. Check the latest studies of Claritin.

What is Epiduo?

Epiduo has active ingredients of adapalene; benzoyl peroxide. It is often used in acne. eHealthMe is studying from 1,581 Epiduo users. Check the latest studies of Epiduo.

On Jul, 13, 2026

19 people who take Claritin and Epiduo together, and have interactions are studied.

What are the common drug interactions of Claritin and Epiduo, by gender? *:

female:

Skin exfoliation (removal of the oldest dead skin cells)
Agitation (state of anxiety or nervous excitement)
Blood oestrogen decreased
Blood testosterone decreased
Chemical injury
Crying
Dermatitis allergic (inflammation of the skin due allergic reaction)
Dizziness
Drug ineffective
Erythema (redness of the skin)

male:

Injection site reaction
Latent tuberculosis (hidden tuberculosis)
Depressed mood
Dry skin
Localised infection (infection at the single location)
Mood altered (changes in mood)
Otitis media (inflammation of the middle ear)

What are the common drug interactions of Claritin and Epiduo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Mood altered (changes in mood)
Pain of skin
Rash
Skin exfoliation (removal of the oldest dead skin cells)
Chemical injury
Crying
Depressed mood
Dermatitis allergic (inflammation of the skin due allergic reaction)
Drug ineffective
Erythema (redness of the skin)

20-29:

Dizziness
Otitis media (inflammation of the middle ear)

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 63.16%
Seasonal Allergy (allergic condition due to certain season): 5 people, 26.32%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 21.05%
Hypersensitivity: 2 people, 10.53%
Drowsiness: 2 people, 10.53%
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups): 1 person, 5.26%
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 1 person, 5.26%
Rash Macular (small, flat red spots): 1 person, 5.26%
Psoriasis - Guttate (skin condition in which small, red, and scaly teardrop-shaped spots appear on the arms, legs, and middle of the body): 1 person, 5.26%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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