Claritin and Krystexxa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Claritin (loratadine) and Krystexxa (pegloticase). Common drug interactions include infusion related reaction among females and infusion related reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Claritin and Krystexxa. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Claritin?

Claritin has active ingredients of loratadine. It is often used in allergies. eHealthMe is studying from 77,316 Claritin users. Check the latest studies of Claritin.

What is Krystexxa?

Krystexxa has active ingredients of pegloticase. eHealthMe is studying from 2,548 Krystexxa users. Check the latest studies of Krystexxa.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

36 people who take Claritin and Krystexxa together, and have interactions are studied.

Claritin and Krystexxa drug interactions.

What are the common drug interactions of Claritin and Krystexxa, by gender? *:

female:

Infusion related reaction
Drug ineffective
Blood pressure increased
Hyperhidrosis (abnormally increased sweating)
Abdominal pain upper
Therapeutic response decreased (less preventive response)
Asthenia (weakness)
Chest pain
Fatigue (feeling of tiredness)
Feeling hot

male:

Infusion related reaction
Gout (uric acid crystals building up in the body)
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Type iv hypersensitivity reaction (delayed type hypersensitivity as the reaction takes two to three days to develop)
Affect lability (emotional incontinence)
Anaemia (lack of blood)
Depression
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Malaise (a feeling of general discomfort or uneasiness)

What are the common drug interactions of Claritin and Krystexxa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Infusion related reaction
Drug ineffective
Therapeutic response decreased (less preventive response)
Blood uric acid increased
Gout (uric acid crystals building up in the body)

40-49:

Infusion related reaction
Drug ineffective
Abdominal pain upper
Blood pressure increased
Hyperhidrosis (abnormally increased sweating)
Blood uric acid increased
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Anaphylactic reaction (serious allergic reaction)
Gout (uric acid crystals building up in the body)
Therapeutic response decreased (less preventive response)

50-59:

Therapeutic response decreased (less preventive response)
Infusion related reaction
Anaphylactic reaction (serious allergic reaction)
Blood uric acid increased
Contusion (a type of hematoma of tissue in which capillaries)
Fall
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Pruritus (severe itching of the skin)
Swollen tongue (swelling of tongue)

60+:

Gout (uric acid crystals building up in the body)
Chest pain
Diarrhoea
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Pruritus (severe itching of the skin)
Weight decreased
Weight increased
Hypersensitivity
Asthenia (weakness)
Blood pressure increased

What are the existing conditions these people have? *

Gout (uric acid crystals building up in the body): 30 people, 83.33%
Gouty Tophus (a deposit of urates in the skin and tissue around a joint or in the external ear): 5 people, 13.89%
Urticaria (rash of round, red welts on the skin that itch intensely): 2 people, 5.56%
Pain: 2 people, 5.56%
Muscle Spasms (muscle contraction): 2 people, 5.56%
Back Pain: 2 people, 5.56%
Asthma: 2 people, 5.56%
Arrhythmias (irregular heartbeat): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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