Claritin and Phenytoin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Claritin (loratadine) and Phenytoin (phenytoin). Common drug interactions include cold sweat among females and vomiting among males.

The phase IV clinical study analyzes what interactions people have when they take Claritin and Phenytoin. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Claritin?

Claritin has active ingredients of loratadine. It is often used in allergies. eHealthMe is studying from 77,317 Claritin users. Check the latest studies of Claritin.

What is Phenytoin?

Phenytoin has active ingredients of phenytoin. It is often used in epilepsy. eHealthMe is studying from 15,753 Phenytoin users. Check the latest studies of Phenytoin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

24 people who take Claritin and Phenytoin together, and have interactions are studied.

Claritin and Phenytoin drug interactions.

What are the common drug interactions of Claritin and Phenytoin, by gender? *:

female:

Cold sweat
Cough
Decreased appetite
Delayed recovery from anaesthesia
Diabetes mellitus inadequate control
Drug effect increased
Dysarthria (speech disorder)
Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)
Electrocardiogram st-t change

male:

Vomiting
Death
Anaemia (lack of blood)
Angiopathy (generic term for a disease of the blood vessels)
Ankle fracture
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Aspartate aminotransferase increased
Back disorder
Blood alkaline phosphatase increased

What are the common drug interactions of Claritin and Phenytoin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Anxiety
Death
Depression
Fear
Injury
Multi-organ failure (multisystem organ failure)
Pain
Renal failure (kidney dysfunction)

10-19:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood potassium increased
Cough
Fatigue (feeling of tiredness)
Gamma-glutamyltransferase increased
Malaise (a feeling of general discomfort or uneasiness)
Nephritis interstitial (a kidney condition characterized by swelling in between the kidney tubules)
Post streptococcal glomerulonephritis (inflammation of the kidney tubules)

20-29:

Bradycardia (abnormally slow heart action)
Cardiac arrest
Circulatory collapse
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hypertension (high blood pressure)
Oxygen saturation decreased
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)

30-39:

Acidosis (build-up of carbon dioxide in the blood)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Death
Delayed recovery from anaesthesia
Injury
Pain
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary infarction (death of a small area of lung)
Respiration (transport of oxygen from the outside air to the cells within tissues)
Respiratory depression (respiration has a rate below 12 breaths)

40-49:

Angiopathy (generic term for a disease of the blood vessels)
Ankle fracture
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back disorder
Dyspnoea (difficult or laboured respiration)
Fall
Foot fracture
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)

50-59:

Dysuria (painful or difficult urination)
Emotional distress
Fatigue (feeling of tiredness)
Gout (uric acid crystals building up in the body)
Human rhinovirus test positive
Hypertension (high blood pressure)
Influenza like illness
Nephropathy (damage to or disease of a kidney)
Pyrexia (fever)
Renal failure (kidney dysfunction)

60+:

International normalised ratio increased
Confusional state
Anxiety
Aortic valve sclerosis (narrowing of the aortic valve)
Arrhythmia (irregular heartbeat)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial hypertrophy (a condition where the left atrium or right atrium of the heart is larger than would be expected)
Atrial tachycardia (rhythm disturbance that arises in the atria)
Atrioventricular block first degree (heart block first degree)

What are the existing conditions these people have? *

Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 3 people, 12.50%
B-Cell Small Lymphocytic Lymphoma (blood cancer affecting b cells): 3 people, 12.50%
Circadian Rhythm Sleep Disorder (family of sleep disorders affecting, among other things, the timing of sleep): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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