Claritin and Savella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Claritin (loratadine) and Savella (milnacipran hydrochloride). Common drug interactions include blood thyroid stimulating hormone increased among females and completed suicide among males.

The phase IV clinical study analyzes what interactions people have when they take Claritin and Savella. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Claritin?

Claritin has active ingredients of loratadine. It is often used in allergies. eHealthMe is studying from 77,317 Claritin users. Check the latest studies of Claritin.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

73 people who take Claritin and Savella together, and have interactions are studied.

What are the common drug interactions of Claritin and Savella, by gender? *:

female:

Blood thyroid stimulating hormone increased
Burning sensation
Chest discomfort
Chills (felling of cold)
Malaise (a feeling of general discomfort or uneasiness)
Diarrhoea
Gastric disorder (disease of stomach)
Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Influenza

male:

Completed suicide (act of taking one's own life)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Nightmare (unpleasant dream)
Petit mal epilepsy (absence seizure)
Sinusitis (inflammation of sinus)
Stress
Therapeutic response unexpected

What are the common drug interactions of Claritin and Savella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Angioedema (rapid swelling of the dermis)
Aphthous ulcer (mouth ulcer)
Bone pain
Headache (pain in head)
Injection site pain
Kidney infection
Nausea (feeling of having an urge to vomit)
Oral discomfort (pain or irritation in mouth)
Pain in extremity
Abdominal pain upper

30-39:

Hypertension (high blood pressure)
Anxiety
Fatigue (feeling of tiredness)
Lymph node pain
Lymphadenitis (inflammation or enlargement of a lymph node)
Nightmare (unpleasant dream)
Rash macular (small, flat red spots)
Scratch
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Stress

40-49:

Therapeutic response delayed (late preventive response)
Urticaria (rash of round, red welts on the skin that itch intensely)
Vaginal discharge
Vitamin d decreased
Wrist surgery
Completed suicide (act of taking one's own life)
Upper respiratory tract infection
Candidiasis (candidiasis or thrush is a fungal infection)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pruritus (severe itching of the skin)

50-59:

Hot flush (sudden feelings of heat)
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Abdominal discomfort
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Arthralgia (joint pain)
Asthma
Corneal disorder
Dry skin
Dysphonia (speech disorder attributable to a disorder of phonation)

60+:

Blood potassium decreased
Cardiac arrest
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Weight decreased
Vomiting
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Oedema peripheral (superficial swelling)
Headache (pain in head)
Infusion related reaction

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 23 people, 31.51%
Pain: 18 people, 24.66%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 15.07%
Hypersensitivity: 10 people, 13.70%
Stress And Anxiety: 9 people, 12.33%
Nausea (feeling of having an urge to vomit): 6 people, 8.22%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 8.22%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 6.85%
Migraine (headache): 5 people, 6.85%
Joint Pain: 5 people, 6.85%

* Approximation only. Some reports may have incomplete information.

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