Cleocin and Tylenol w/ codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cleocin (clindamycin phosphate) and Tylenol w/ codeine (acetaminophen; codeine phosphate). Common drug interactions include pleural effusion among females and colitis pseudomembranous among males.

The phase IV clinical study analyzes what interactions people have when they take Cleocin and Tylenol w/ codeine. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Cleocin?

Cleocin has active ingredients of clindamycin phosphate. It is often used in infection. eHealthMe is studying from 3,940 Cleocin users. Check the latest studies of Cleocin.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

24 people who take Cleocin and Tylenol w/ codeine together, and have interactions are studied.

Cleocin and Tylenol w/ codeine drug interactions.

What are the common drug interactions of Cleocin and Tylenol W/ Codeine, by gender? *:

female:

Pleural effusion (water on the lungs)
Spinal compression fracture (fracture due to spinal compression on bone)
Swelling face
Cardiomegaly (increased size of heart than normal)
Osteonecrosis of jaw (death of bone of jaw)
Atelectasis (partial or complete collapse of the lung)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Visual impairment
Cardiac disorder
Abscess neck (neck abscesses)

male:

Colitis pseudomembranous (antibiotic-associated diarrhoea)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Electrolyte imbalance
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrointestinal necrosis (destruction of gastrointestinal organ)
Hypotension (abnormally low blood pressure)
Intestinal obstruction
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the common drug interactions of Cleocin and Tylenol W/ Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Blood amylase increased
Cardiac disorder
Drug ineffective
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Type 1 diabetes mellitus
Vomiting

30-39:

n/a

40-49:

n/a

50-59:

Cellulitis (infection under the skin)
Coagulopathy (blood's ability to clot is impaired)
Contusion (a type of hematoma of tissue in which capillaries)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Deafness
Decreased appetite
Dilatation ventricular
Diplopia (double vision)
Dysgeusia (disorder of the sense of taste)
Dysphagia (a condition in which swallowing is difficult or painful)

60+:

Anxiety
Balance disorder
Dysgeusia (disorder of the sense of taste)
Dyspnoea exertional (breathlessness or shortness of breath)
Endometrial disorder
Fall
Gingival swelling (gums swelling)
Haemangioma of liver (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in liver)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hypophagia (reduced food intake)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 9 people, 37.50%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 9 people, 37.50%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 5 people, 20.83%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 4 people, 16.67%
Constipation: 4 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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