Clexane and Isosorbide mononitrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clexane (enoxaparin sodium) and Isosorbide mononitrate (isosorbide mononitrate). Common drug interactions include renal failure chronic among females and myocardial infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Clexane and Isosorbide mononitrate. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Clexane?

Clexane has active ingredients of enoxaparin sodium. eHealthMe is studying from 14,679 Clexane users. Check the latest studies of Clexane.

What is Isosorbide mononitrate?

Isosorbide mononitrate has active ingredients of isosorbide mononitrate. It is often used in angina. eHealthMe is studying from 26,858 Isosorbide mononitrate users. Check the latest studies of Isosorbide mononitrate.



On Jul, 12, 2026

26 people who take Clexane and Isosorbide mononitrate together, and have interactions are studied.

Clexane and Isosorbide mononitrate drug interactions.

What are the common drug interactions of Clexane and Isosorbide Mononitrate, by gender? *:

female:

  1. Renal failure chronic (long lasting kidney dysfunction)
  2. Abdominal pain
  3. Abscess (pus)
  4. Activated partial thromboplastin time prolonged
  5. Acute circulatory failure (shock)
  6. Acute myocardial infarction (acute heart attack)
  7. Anaemia (lack of blood)
  8. Articular calcification
  9. Bacterial infection
  10. Blood creatinine increased

male:

  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  2. Pneumonia
  3. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  4. Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
  5. Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
  6. Dyspnoea (difficult or laboured respiration)
  7. Epistaxis (bleed from the nose)
  8. Generalised oedema (swelling all over the body)
  9. Headache (pain in head)
  10. Hepatic necrosis (large portions of liver die off due to severe liver disease)

What are the common drug interactions of Clexane and Isosorbide Mononitrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Abdominal pain
  2. Chest pain
  3. Dyspnoea (difficult or laboured respiration)
  4. Headache (pain in head)
  5. Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)
  6. Neutropenia (an abnormally low number of neutrophils)
  7. Acute myocardial infarction (acute heart attack)
  8. Articular calcification
  9. Bacterial infection
  10. Blood culture positive

50-59:

  1. Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
  2. Generalised oedema (swelling all over the body)
  3. Hypotension (abnormally low blood pressure)
  4. Pruritus generalised (generalized itching)
  5. Renal failure chronic (long lasting kidney dysfunction)
  6. Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
  7. Skin exfoliation (removal of the oldest dead skin cells)
  8. Atrioventricular block complete (heart block complete)
  9. Bradycardia (abnormally slow heart action)
  10. Cardiac aneurysm (a condition that can occur after a myocardial infarction due to the inadequate resistance of the new scar tissue to the systolic pressure)

60+:

  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  2. Pneumonia
  3. Hepatitis (inflammation of the liver)
  4. Hepatorenal failure (decrease in kidney function in a person with a severe liver disorder)
  5. Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
  6. Lung disorder (lung disease)
  7. Oedema lower limb (fluid collection in tissue of lower leg)
  8. Pancreatic disorder
  9. Pancreatitis (inflammation of pancreas)
  10. Petechiae (a small red or purple spot caused by bleeding into the skin)

What are the existing conditions these people have? *

  1. High Blood Pressure: 5 people, 19.23%
  2. Thrombolysis (resolving the blood clot): 3 people, 11.54%
  3. Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 3 people, 11.54%
  4. Pneumonia: 2 people, 7.69%
  5. Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 2 people, 7.69%
  6. Lung Infection: 2 people, 7.69%
  7. Heart Attack: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Clexane and Isosorbide mononitrate?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Clexane and Isosorbide mononitrate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Clexane:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Isosorbide mononitrate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Clexane and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Isosorbide mononitrate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on enoxaparin sodium and isosorbide mononitrate (the active ingredients of Clexane and Isosorbide mononitrate, respectively), and Clexane and Isosorbide mononitrate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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