Palladone and Clexane drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Palladone (hydromorphone hydrochloride) and Clexane (enoxaparin sodium). Common drug interactions include thrombosis among females and pelvic fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Palladone and Clexane. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Palladone?

Palladone has active ingredients of hydromorphone hydrochloride. eHealthMe is studying from 2,546 Palladone users. Check the latest studies of Palladone.

What is Clexane?

Clexane has active ingredients of enoxaparin sodium. eHealthMe is studying from 14,679 Clexane users. Check the latest studies of Clexane.

On Feb, 14, 2026

29 people who take Palladone and Clexane together, and have interactions are studied.

Palladone and Clexane drug interactions.

What are the common drug interactions of Palladone and Clexane, by gender? *:

female:

Thrombosis (formation of a blood clot inside a blood vessel)
White blood cell count decreased
Pain in extremity
General physical health deterioration (weak health status)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic thrombosis (formation of a blood clot inside aorta)
Cerebral microangiopathy (small-vessel disease of brain)
Diplopia (double vision)
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)

male:

Pelvic fracture
Postoperative wound infection
Fall
General physical health deterioration (weak health status)
Myoglobin blood increased (presence of myoglobin in blood increased)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Psychomotor hyperactivity (feelings of extreme restlessness)
Pyrexia (fever)

What are the common drug interactions of Palladone and Clexane, by age (0-1 to 60+)? *:

0-1:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Gestational diabetes (diabetes in pregnancy)
Maternal exposure during pregnancy (use of substance during pregnancy)
Premature labour

40-49:

Diarrhoea
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

50-59:

Skin infection
Mucosal inflammation (infection of mucous membrane)
White blood cell count decreased
Acute respiratory distress syndrome
Arthralgia (joint pain)
Fatigue (feeling of tiredness)
General physical health deterioration (weak health status)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Neutropenia (an abnormally low number of neutrophils)
Pyrexia (fever)

60+:

Pelvic fracture
Postoperative wound infection
Coronary artery bypass
Fall
Fatigue (feeling of tiredness)
Myoglobin blood increased (presence of myoglobin in blood increased)
Nausea (feeling of having an urge to vomit)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 5 people, 17.24%
High Blood Pressure: 5 people, 17.24%
Multiple Myeloma (cancer of the plasma cells): 4 people, 13.79%
Metastases To Bone (cancer spreads to bone): 4 people, 13.79%
Nausea (feeling of having an urge to vomit): 3 people, 10.34%
Tumor Pain: 2 people, 6.90%
Gastritis (inflammation of stomach): 2 people, 6.90%
Allergies: 2 people, 6.90%
Bone Pain: 2 people, 6.90%
Cardiac Disorder: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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