Climara and Actonel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Climara (estradiol) and Actonel (risedronate sodium). Common drug interactions include postoperative renal failure among females and bone density decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Climara and Actonel. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Climara?

Climara has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,706 Climara users. Check the latest studies of Climara.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

On Jul, 13, 2026

35 people who take Climara and Actonel together, and have interactions are studied.

What are the common drug interactions of Climara and Actonel, by gender? *:

female:

Postoperative renal failure
Psoriasis (immune-mediated disease that affects the skin)
Restless legs syndrome (a powerful urge to move your legs)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Surgery
Urinary tract infection
Vertigo
Agitation (state of anxiety or nervous excitement)
Alanine aminotransferase increased
Arthropathy

male:

Bone density decreased
Calcium deficiency (lack of calcium)
Injection site swelling
Ligament sprain (ligament stretched)
Osteoporotic fracture (fracture due to weak bone)
Spinal compression fracture (fracture due to spinal compression on bone)
Spinal fracture (fracture in one of vertebrae)
Vitamin d deficiency
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cubital tunnel syndrome (a condition brought on by increased pressure on the ulnar nerve at the elbow)

What are the common drug interactions of Climara and Actonel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Hyperthermia (body temperature greatly above normal)
Hypotension (abnormally low blood pressure)
Leukopenia (less number of white blood cells in blood)
Petechiae (a small red or purple spot caused by bleeding into the skin)
Serositis (inflammation of the serous tissues of the body)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Thrombocytopenia (decrease of platelets in blood)
Agitation (state of anxiety or nervous excitement)
Cardiac disorder
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)

50-59:

Osteonecrosis (death of bone)
Respiratory disorder (respiratory disease)
Small intestinal haemorrhage (bleeding from small intestine)
Stomatitis (inflammation of mucous membrane of mouth)
Tooth disorder (tooth disease)
Toothache (tooth pain)
Vomiting
Anxiety
Electrocardiogram qt prolonged
Pruritus (severe itching of the skin)

60+:

Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes)
Bone disorder
Cubital tunnel syndrome (a condition brought on by increased pressure on the ulnar nerve at the elbow)
Epicondylitis (tennis elbow)
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium)
Injection site erythema (redness at injection site)
Injection site pruritus (severe itching at injection site)
Injection site rash
Injection site reaction
Injection site swelling

What are the existing conditions these people have? *

Osteopenia (a condition where bone mineral density is lower than normal): 8 people, 22.86%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 20.00%
Gastrointestinal Motility Disorder (abnormal intestinal contractions): 5 people, 14.29%
Thyroid Diseases: 2 people, 5.71%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 5.71%
Pituitary Tumor Benign: 2 people, 5.71%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 5.71%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 2 people, 5.71%
Constipation: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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