Climara and Augmentin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Climara (estradiol) and Augmentin (amoxicillin; clavulanate potassium). Common drug interactions include headache among females.

The phase IV clinical study analyzes what interactions people have when they take Climara and Augmentin. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Climara?

Climara has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,706 Climara users. Check the latest studies of Climara.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

20 people who take Climara and Augmentin together, and have interactions are studied.

Climara and Augmentin drug interactions.

What are the common drug interactions of Climara and Augmentin, by gender? *:

female:

Headache (pain in head)
Device intolerance
Drug hypersensitivity
Fibrocystic breast disease (a condition causing breast pain, cysts, and noncancerous breast lumps, affects many women)
Postoperative thrombosis (formation of a blood clot inside a blood vessel after operative)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Breast microcalcification (deposits of calcium that can be seen on a mammogram of the breast)
Chronic kidney disease
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Eating disorder

male:

n/a

What are the common drug interactions of Climara and Augmentin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Fibrocystic breast disease (a condition causing breast pain, cysts, and noncancerous breast lumps, affects many women)
Postoperative thrombosis (formation of a blood clot inside a blood vessel after operative)
Weight increased
Breast microcalcification (deposits of calcium that can be seen on a mammogram of the breast)
Chronic kidney disease
Electrocardiogram st-t change
Radiation skin injury
Alopecia (absence of hair from areas of the body)
Anxiety
Aortic valve incompetence

60+:

Device intolerance
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Headache (pain in head)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Peripheral swelling
Pruritus (severe itching of the skin)
Drug hypersensitivity
Conjunctivitis (pink eye)

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 30.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 30.00%
Vulvovaginal Dryness: 1 person, 5.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 5.00%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 1 person, 5.00%
Depression: 1 person, 5.00%
Drowsiness: 1 person, 5.00%
Fungal Infection: 1 person, 5.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.00%
Headache (pain in head): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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