Climara and Modafinil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Climara (estradiol) and Modafinil (modafinil). Common drug interactions include arthralgia among females.

The phase IV clinical study analyzes what interactions people have when they take Climara and Modafinil. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Climara?

Climara has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,706 Climara users. Check the latest studies of Climara.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

19 people who take Climara and Modafinil together, and have interactions are studied.

Climara and Modafinil drug interactions.

What are the common drug interactions of Climara and Modafinil, by gender? *:

female:

Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Drug ineffective
Ear infection
Electrocardiogram pr prolongation
Electrocardiogram qt prolonged
Fatigue (feeling of tiredness)
Gait disturbance
Influenza
Migraine (headache)

male:

n/a

What are the common drug interactions of Climara and Modafinil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Influenza
Panic attack

30-39:

n/a

40-49:

n/a

50-59:

Gait disturbance

60+:

Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Hepatic enzyme increased
Incoherent (talking in a confused and unclear way)
Knee arthroplasty
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Bradycardia (abnormally slow heart action)
Electrocardiogram pr prolongation
Electrocardiogram qt prolonged

What are the existing conditions these people have? *

Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 26.32%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 21.05%
Pain: 2 people, 10.53%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 10.53%
Breakthrough Pain: 2 people, 10.53%
Drowsiness: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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