Clindamycin hydrochloride and Chlorhexidine gluconate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clindamycin hydrochloride (clindamycin hydrochloride) and Chlorhexidine gluconate (chlorhexidine gluconate). Common drug interactions include aphthous stomatitis among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Clindamycin hydrochloride and Chlorhexidine gluconate. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Clindamycin hydrochloride?

Clindamycin hydrochloride has active ingredients of clindamycin hydrochloride. It is often used in tooth abscess. eHealthMe is studying from 4,257 Clindamycin hydrochloride users. Check the latest studies of Clindamycin hydrochloride.

What is Chlorhexidine gluconate?

Chlorhexidine gluconate has active ingredients of chlorhexidine gluconate. eHealthMe is studying from 8,233 Chlorhexidine gluconate users. Check the latest studies of Chlorhexidine gluconate.

On Jul, 04, 2026

61 people who take Clindamycin hydrochloride and Chlorhexidine gluconate together, and have interactions are studied.

Clindamycin hydrochloride and Chlorhexidine gluconate drug interactions.

What are the common drug interactions of Clindamycin Hydrochloride and Chlorhexidine Gluconate, by gender? *:

female:

Aphthous stomatitis (mouth ulcer)
Back pain
Depressed mood
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Haematemesis (vomiting of blood)
Hot flush (sudden feelings of heat)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Osteonecrosis (death of bone)
Otitis media acute (rapid inflammation of the middle ear)
Rib fracture

male:

Pain
Abdominal pain upper
Chills (felling of cold)
Decreased appetite
Discomfort
Extraskeletal ossification (formation of bone tissue outside of bone tissue)
Gastrointestinal inflammation (inflammation of stomach and intestine)
Gingival pain (gum pain)
Haemorrhage (bleeding)
Heart rate increased

What are the common drug interactions of Clindamycin Hydrochloride and Chlorhexidine Gluconate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Injection site pain

20-29:

Abdominal pain upper
Blood pressure decreased
Chills (felling of cold)
Decreased appetite
Discomfort
Gastrointestinal inflammation (inflammation of stomach and intestine)
Haemorrhage (bleeding)
Heart rate increased
Heart rate irregular
Hot flush (sudden feelings of heat)

30-39:

n/a

40-49:

Abdominal pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Bone cyst
Bone density decreased
Cerebral haemorrhage (bleeding within the brain)
Chronic kidney disease
Depression
Emotional distress

50-59:

Injury
Jaw disorder (jaw disease)
Mastication disorder (disease of chewing food)
Mucosal inflammation (infection of mucous membrane)
Neuropathy peripheral (surface nerve damage)
Neutropenia (an abnormally low number of neutrophils)
Osteonecrosis (death of bone)
Otitis media (inflammation of the middle ear)
Pain
Rectal haemorrhage (bleeding from anus)

60+:

Anxiety
Pain
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Fatigue (feeling of tiredness)
Intervertebral disc degeneration (spinal disc degeneration)
Oral pain
Pain in jaw
Spinal column stenosis (narrowing of spinal column)
Spondylolisthesis (displacement of a vertebra or the vertebral column in relation to the vertebrae below)
Swelling

What are the existing conditions these people have? *

Pain: 8 people, 13.11%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 8 people, 13.11%

* Approximation only. Some reports may have incomplete information.

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