Clolar and Bactrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clolar (clofarabine) and Bactrim (sulfamethoxazole; trimethoprim). Common drug interactions include device related infection among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Clolar and Bactrim. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Clolar?

Clolar has active ingredients of clofarabine. eHealthMe is studying from 1,093 Clolar users. Check the latest studies of Clolar.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

On Aug, 06, 2026

47 people who take Clolar and Bactrim together, and have interactions are studied.

What are the common drug interactions of Clolar and Bactrim, by gender? *:

female:

Device related infection
Lipase increased
Pancreatitis (inflammation of pancreas)
Pneumonia
Anaemia (lack of blood)
Thrombocytopenia (decrease of platelets in blood)
Blood amylase increased
Hypoxia (low oxygen in tissues)
Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

male:

Hypotension (abnormally low blood pressure)
Thrombocytopenia (decrease of platelets in blood)
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Aspergillosis (an infection caused by a fungus called aspergillus)
Enterococcal bacteraemia (presence of bacteria lactic acid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Mucosal inflammation (infection of mucous membrane)
Nocardiosis (an infectious disease affecting either the lungs or whole body)

What are the common drug interactions of Clolar and Bactrim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Lipase increased
Neutropenia (an abnormally low number of neutrophils)
Device related infection
Neutropenic infection (infection with less neutrophil numbers in blood)
Pancreatitis (inflammation of pancreas)
Pneumonia
Blood amylase increased
Hypoxia (low oxygen in tissues)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Staphylococcal bacteraemia (a bacterial infection of blood)

10-19:

Hypotension (abnormally low blood pressure)
Renal failure (kidney dysfunction)
Febrile neutropenia (fever with reduced white blood cells)
Pain in extremity
Pyrexia (fever)
Vomiting
Anaemia (lack of blood)
Lung neoplasm (tumour of lung)
Mucosal inflammation (infection of mucous membrane)
Oral herpes (viral infection of mouth)

20-29:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Hypotension (abnormally low blood pressure)
Abdominal pain
Ascites (accumulation of fluid in the abdominal cavity)
Cardiac arrest
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Enteritis (inflammation of the small intestine)
Enterococcal bacteraemia (presence of bacteria lactic acid in the blood)
Infusion related reaction
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

30-39:

Hyperaesthesia
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Hypokalaemia (low potassium)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Multi-organ failure (multisystem organ failure)
Myalgia (muscle pain)
Myositis (inflammation of the muscles)
Nausea (feeling of having an urge to vomit)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Vomiting

40-49:

Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)
Cytomegalovirus infection
Graft versus host disease in skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin)

50-59:

Aphasia (damage to the parts of the brain that control language)
Confusional state
Dry mouth
Fall
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Graft versus host disease in intestine (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body and damages intestinal mucosal membrane)
Muscular weakness (muscle weakness)
Proctalgia (pain in the rectum)

60+:

Thrombocytopenia (decrease of platelets in blood)
Renal failure (kidney dysfunction)
Nocardiosis (an infectious disease affecting either the lungs or whole body)
Small intestinal obstruction (blockage in small intestine)
Transaminases increased
Renal impairment (severely reduced kidney function)
Cardiac arrest
Coagulopathy (blood's ability to clot is impaired)
Depressed level of consciousness
Diastolic dysfunction

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 18 people, 38.30%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 11 people, 23.40%
Burkitt Lymphoma (cancer of the lymphatic system): 4 people, 8.51%
Acute Myeloid Leukaemia Recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent): 4 people, 8.51%
Nausea (feeling of having an urge to vomit): 3 people, 6.38%
Bone Marrow Conditioning Regimen: 3 people, 6.38%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 3 people, 6.38%
Acute Lymphocytic Leukaemia Recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent): 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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