Clozapine and Doxycycline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clozapine (clozapine) and Doxycycline (doxycycline hyclate). Common drug interactions include oral discomfort among females and hallucination among males.

The phase IV clinical study analyzes what interactions people have when they take Clozapine and Doxycycline. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.

What is Clozapine?

Clozapine has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 83,728 Clozapine users. Check the latest studies of Clozapine.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,866 Doxycycline users. Check the latest studies of Doxycycline.

On Jul, 16, 2026

96 people who take Clozapine and Doxycycline together, and have interactions are studied.

Clozapine and Doxycycline drug interactions.

What are the common drug interactions of Clozapine and Doxycycline, by gender? *:

female:

Oral discomfort (pain or irritation in mouth)
Oral pain
Pruritus (severe itching of the skin)
Slow speech
Influenza
Gait disturbance
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Infrequent bowel movements
Drug level below therapeutic
Faeces hard

male:

Hallucination (an experience involving the perception of something not present)
Confusional state
Dyspnoea (difficult or laboured respiration)
Pneumonia
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Overdose
Sepsis (a severe blood infection that can lead to organ failure and death)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

What are the common drug interactions of Clozapine and Doxycycline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Granulocytopenia (lack of granulocyte)
Decreased appetite
Nausea (feeling of having an urge to vomit)
Vomiting
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Agitation (state of anxiety or nervous excitement)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Delusion (a false belief or opinion)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)

20-29:

Staphylococcal infection (an infection with staphylococcus bacteria)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hypotension (abnormally low blood pressure)
Overdose
Sepsis (a severe blood infection that can lead to organ failure and death)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Confusional state
Delirium (wild excitement)
Suicide attempt
Drug ineffective

30-39:

Fall
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Spinal osteoarthritis (joint cartilage loss in spine)
Depression
Femur fracture
Forearm fracture (fracture in between wrist to elbow)
Gastric ulcer (stomach ulcer)
Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Lower limb fracture

40-49:

Hypophagia (reduced food intake)
Metabolic disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues)
Myocarditis (inflammation of heart muscle myocardium)
Psychiatric decompensation (worsening of symptoms to the state of a serious mental disorder)
Salivary hypersecretion (excess saliva secretion)
Sedation
Sepsis (a severe blood infection that can lead to organ failure and death)
Asthma
Lower respiratory tract infection
Malaise (a feeling of general discomfort or uneasiness)

50-59:

Drug level increased
Stupor (lack of critical cognitive function and level of consciousness)
Upper respiratory tract infection
Anger
Anxiety
Confusional state
Hallucination (an experience involving the perception of something not present)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Bandaemia (excess of band cells (immature white blood cells) released by the bone marrow into the blood)
Neutropenia (an abnormally low number of neutrophils)

60+:

Hallucination (an experience involving the perception of something not present)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Fear
Hypoacusis (loss of hearing)
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Oral discomfort (pain or irritation in mouth)
Oral pain
Pruritus (severe itching of the skin)

What are the existing conditions these people have? *

Parkinson's Disease: 21 people, 21.88%
High Blood Pressure: 7 people, 7.29%
Quit Smoking: 5 people, 5.21%
Hallucinations (sensations that appear real but are created by your mind): 5 people, 5.21%
Hallucination, Tactile (sensation of physical contact with an object that isn't there): 5 people, 5.21%
Cardiac Disorder: 5 people, 5.21%

* Approximation only. Some reports may have incomplete information.

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