Clozaril and Aldactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clozaril (clozapine) and Aldactone (spironolactone). Common drug interactions include diabetes mellitus among females and red blood cell count decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Clozaril and Aldactone. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Clozaril?

Clozaril has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 65,127 Clozaril users. Check the latest studies of Clozaril.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

On Jul, 13, 2026

31 people who take Clozaril and Aldactone together, and have interactions are studied.

Clozaril and Aldactone drug interactions.

What are the common drug interactions of Clozaril and Aldactone, by gender? *:

female:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
White blood cell count decreased
Blood cholesterol increased
Cardiac disorder
Confusion
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Eosinophil count decreased
Haematocrit decreased
Haemoglobin decreased
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)

male:

Red blood cell count decreased
Body temperature decreased
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Ascites (accumulation of fluid in the abdominal cavity)
Blood bilirubin increased
Cardiomegaly (increased size of heart than normal)
Cardiomyopathy (weakening of the heart muscle)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Fluid retention (an abnormal accumulation of fluid in the blood)
Hypotension (abnormally low blood pressure)

What are the common drug interactions of Clozaril and Aldactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiomegaly (increased size of heart than normal)
Agitation (state of anxiety or nervous excitement)
Alanine aminotransferase increased
Aortic dilatation
Blood uric acid increased
Cardiac failure
Congestive cardiomyopathy (weakening of heart muscle)
Dilatation ventricular
Dyspnoea (difficult or laboured respiration)
Ejection fraction decreased (systolic heart failure)

30-39:

n/a

40-49:

Ascites (accumulation of fluid in the abdominal cavity)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Blood bilirubin increased
Cardiac disorder
Abdominal distension
Blood cholesterol increased
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Renal failure (kidney dysfunction)
Anion gap increased

50-59:

Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Syncope (loss of consciousness with an inability to maintain postural tone)
Tardive dyskinesia (a disorder that involves involuntary movements)
Vomiting
Weight increased
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Eosinophil count decreased
Haematocrit decreased
Haemoglobin decreased
Influenza

60+:

White blood cell count decreased
Confusion
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Platelet count decreased
Renal impairment (severely reduced kidney function)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Ammonia increased
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)

What are the existing conditions these people have? *

Sleep Disorder: 3 people, 9.68%
High Blood Pressure: 3 people, 9.68%
Stress And Anxiety: 2 people, 6.45%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 2 people, 6.45%
Post-Traumatic Stress Disorder: 2 people, 6.45%
High Blood Cholesterol: 2 people, 6.45%
Bipolar Disorder (mood disorder): 2 people, 6.45%
Affective Disorder (mental disorder): 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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