Clozaril and Prolia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clozaril (clozapine) and Prolia (denosumab). Common drug interactions include myocardial infarction among females and delusion of grandeur among males.

The phase IV clinical study analyzes what interactions people have when they take Clozaril and Prolia. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Clozaril?

Clozaril has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 65,127 Clozaril users. Check the latest studies of Clozaril.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,388 Prolia users. Check the latest studies of Prolia.

On Aug, 08, 2026

23 people who take Clozaril and Prolia together, and have interactions are studied.

What are the common drug interactions of Clozaril and Prolia, by gender? *:

female:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain
Rash
Urinary tract infection
Urticaria (rash of round, red welts on the skin that itch intensely)
Vomiting
Headache (pain in head)
Acute respiratory failure
Cardiac failure
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)

male:

Delusion of grandeur
Hallucination, auditory (perceiving sounds without auditory stimulus)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Respiratory syncytial virus bronchiolitis (a lower respiratory tract infection due to virus)
Cardiac failure congestive
Congestive cardiomyopathy (weakening of heart muscle)
Device occlusion
Finger deformity (a deformed position of the finger)
Joint range of motion decreased (disease of joint movement)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

What are the common drug interactions of Clozaril and Prolia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Psychotic disorder
Rash
Red blood cell count decreased
Red cell distribution width increased
Sleep disorder due to general medical condition, insomnia type (a conditions that prevent a person from getting restful sleep due to mental condition of not getting sleep)
Spinal cord injury
Tension (the act or process of stretching something tight)
Thrombocytopenia (decrease of platelets in blood)
Toothache (tooth pain)
Vitamin b12 decreased

30-39:

n/a

40-49:

Anaemia (lack of blood)
Arthralgia (joint pain)
Cardiac failure congestive
Congestive cardiomyopathy (weakening of heart muscle)
Finger deformity (a deformed position of the finger)
Joint range of motion decreased (disease of joint movement)
Metastases to breast (cancer spreads to brain)
Metastatic neoplasm (spreadable cancer tumour)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Oedema peripheral (superficial swelling)

50-59:

Delusion of grandeur
Hallucination, auditory (perceiving sounds without auditory stimulus)
Neutropenia (an abnormally low number of neutrophils)
Arthralgia (joint pain)
Bone pain
Dementia (madness)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

60+:

Leukocytosis (increased white blood cells)
Leukopenia (less number of white blood cells in blood)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Respiratory syncytial virus bronchiolitis (a lower respiratory tract infection due to virus)
White blood cell count increased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood glucose increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the existing conditions these people have? *

Parkinson's Disease: 4 people, 17.39%
Pain: 4 people, 17.39%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 3 people, 13.04%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 2 people, 8.70%
Neuropsychiatric Lupus (the various psychiatric and neurologic symptoms due to a multi system inflammatory disorder): 2 people, 8.70%
Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 2 people, 8.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.70%
Dyspnea (difficult or laboured breathing): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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