Clozaril and Prolixin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clozaril (clozapine) and Prolixin (fluphenazine hydrochloride). Common drug interactions include blindness among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Clozaril and Prolixin. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.

What is Clozaril?

Clozaril has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 65,127 Clozaril users. Check the latest studies of Clozaril.

What is Prolixin?

Prolixin has active ingredients of fluphenazine hydrochloride. It is often used in schizoaffective disorder. eHealthMe is studying from 1,262 Prolixin users. Check the latest studies of Prolixin.

On Jul, 13, 2026

96 people who take Clozaril and Prolixin together, and have interactions are studied.

Clozaril and Prolixin drug interactions.

What are the common drug interactions of Clozaril and Prolixin, by gender? *:

female:

Blindness
Diplopia (double vision)
Drug hypersensitivity
Hepatitis (inflammation of the liver)
Neutropenia (an abnormally low number of neutrophils)
Psychotic disorder
Tremor (trembling or shaking movements in one or more parts of your body)
Type 1 diabetes mellitus
Urinary tract infection
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

male:

Pneumonia
Pyrexia (fever)
Anxiety
Headache (pain in head)
Renal failure acute (rapid kidney dysfunction)
Speech disorder
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting
Weight increased
Akathisia (a movement disorder characterized by a feeling of inner restlessness)

What are the common drug interactions of Clozaril and Prolixin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Aggression

20-29:

Pyrexia (fever)
Psychotic disorder
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Abdominal pain upper
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Delusional disorder, unspecified type
Fatigue (feeling of tiredness)
Influenza like illness
Lymphoma (cancer that begins in immune system cells)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)

30-39:

Agitation (state of anxiety or nervous excitement)
Delusion (a false belief or opinion)
Anxiety
Gait abnormal
Pyrexia (fever)
Renal failure acute (rapid kidney dysfunction)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Arthralgia (joint pain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Confusion

40-49:

Diabetes mellitus inadequate control
Difficulty in micturition (difficulty to urinate)
Drooling (drop saliva uncontrollably from the mouth)
Drug level increased
Drug toxicity
Dyskinesia (abnormality or impairment of voluntary movement)
Dyspnoea (difficult or laboured respiration)
Genital haemorrhage (bleeding from genital)
Gingival pain (gum pain)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)

50-59:

Cardiac disorder
Chest pain
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Alanine aminotransferase increased
Arrhythmia (irregular heartbeat)
Arteriosclerosis (thickening and hardening of arteries)
Aspartate aminotransferase increased
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Blood triglycerides increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

60+:

Pneumonia
Haematemesis (vomiting of blood)
Hypotension (abnormally low blood pressure)
Loss of consciousness
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Neutropenia (an abnormally low number of neutrophils)
Psychotic disorder
Pyrexia (fever)
Renal injury (kidney injury)
Sedation

What are the existing conditions these people have? *

Depression: 7 people, 7.29%
Bipolar Disorder (mood disorder): 7 people, 7.29%

* Approximation only. Some reports may have incomplete information.

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