Clozaril and Vortioxetine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clozaril (clozapine) and Vortioxetine (vortioxetine). Common drug interactions include mental impairment among females and anion gap increased among males.

The phase IV clinical study analyzes what interactions people have when they take Clozaril and Vortioxetine. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Clozaril?

Clozaril has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 65,127 Clozaril users. Check the latest studies of Clozaril.

What is Vortioxetine?

Vortioxetine has active ingredients of vortioxetine. eHealthMe is studying from 2,440 Vortioxetine users. Check the latest studies of Vortioxetine.

On Jul, 12, 2026

11 people who take Clozaril and Vortioxetine together, and have interactions are studied.

Clozaril and Vortioxetine drug interactions.

What are the common drug interactions of Clozaril and Vortioxetine, by gender? *:

female:

Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Adverse event
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Death
Hospitalisation
Dyspnoea (difficult or laboured respiration)
Lower respiratory tract infection

male:

Anion gap increased
Blood bicarbonate decreased
Oropharyngeal pain
Platelet count decreased
Pyrexia (fever)
Troponin increased
Viral infection
Chest pain
Blood creatine phosphokinase increased
Chest discomfort

What are the common drug interactions of Clozaril and Vortioxetine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Anion gap increased
Blood bicarbonate decreased
C-reactive protein increased
Fatigue (feeling of tiredness)
Headache (pain in head)
Lymphocyte count decreased
Malaise (a feeling of general discomfort or uneasiness)
Mean platelet volume decreased (less than normal average size of platelet cells in blood)
Myalgia (muscle pain)

30-39:

n/a

40-49:

Death
Dyspnoea (difficult or laboured respiration)
Lower respiratory tract infection

50-59:

Change of bowel habit
Eosinophil count decreased
Thrombocytopenia (decrease of platelets in blood)
White blood cell count decreased

60+:

Bacteraemia (presence of bacteria in the blood)
Blood potassium increased
Chest pain
Glomerular filtration rate decreased
Influenza
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Pneumonia pseudomonal (pseudomonas pneumonia is an infection caused by the microbe known as pseudomonas aeruginosa)
White blood cell count increased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Death

What are the existing conditions these people have? *

Salivary Hypersecretion (excess saliva secretion): 2 people, 18.18%
Pain: 2 people, 18.18%
Lower Respiratory Tract Infection: 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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