Co-codamol and Nitrofurantoin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Co-codamol (acetaminophen; codeine phosphate) and Nitrofurantoin (nitrofurantoin, macrocrystalline). Common drug interactions include disorientation among females and blood pressure decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Co-codamol and Nitrofurantoin. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Co-codamol?

Co-codamol has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 2,364 Co-codamol users. Check the latest studies of Co-codamol.

What is Nitrofurantoin?

Nitrofurantoin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 4,840 Nitrofurantoin users. Check the latest studies of Nitrofurantoin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

22 people who take Co-codamol and Nitrofurantoin together, and have interactions are studied.

Co-codamol and Nitrofurantoin drug interactions.

What are the common drug interactions of Co-Codamol and Nitrofurantoin, by gender? *:

female:

Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Jaundice cholestatic
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)
Schizophrenia, paranoid type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect)
Tendonitis (a condition that causes pain and swelling of tendons)
Glomerular filtration rate decreased
Oesophageal cancer metastatic (cancer of oesophagues spreads to other part)

male:

Blood pressure decreased
Blood urea increased
Melaena (the passage of black, tarry stools)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)

What are the common drug interactions of Co-Codamol and Nitrofurantoin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)

60+:

Glomerular filtration rate decreased
Oesophageal cancer metastatic (cancer of oesophagues spreads to other part)
Jaundice cholestatic
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)
Schizophrenia, paranoid type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect)
Tendonitis (a condition that causes pain and swelling of tendons)
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Blood pressure decreased

What are the existing conditions these people have? *

Osteoarthritis (a joint disease caused by cartilage loss in a joint): 8 people, 36.36%
Osteoporosis (bones weak and more likely to break): 5 people, 22.73%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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