Cobalamin and Aldactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cobalamin (vitamin b12) and Aldactone (spironolactone). Common drug interactions include cholecystitis acute among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Cobalamin and Aldactone. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Cobalamin?

Cobalamin has active ingredients of vitamin b12. eHealthMe is studying from 3,429 Cobalamin users. Check the latest studies of Cobalamin.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

On Jul, 15, 2026

11 people who take Cobalamin and Aldactone together, and have interactions are studied.

Cobalamin and Aldactone drug interactions.

What are the common drug interactions of Cobalamin and Aldactone, by gender? *:

female:

Cholecystitis acute (rapid infection of gallbladder)
Hip arthroplasty
Septic shock (shock due to blood infection)
Injection site discolouration
Injection site dryness
Injection site erythema (redness at injection site)
Injection site induration
Injection site pain
Injection site swelling
Nausea (feeling of having an urge to vomit)

male:

Confusional state
Muscle atrophy (a decrease in the mass of the muscle)
Renal failure (kidney dysfunction)
Spider naevus (small dilated blood vessels near the surface of the skin)

What are the common drug interactions of Cobalamin and Aldactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Injection site dryness
Injection site erythema (redness at injection site)
Injection site induration
Injection site pain
Injection site swelling
Nausea (feeling of having an urge to vomit)
Pulmonary alveolar haemorrhage (acute bleeding)
Rash
Weight increased
Injection site discolouration

40-49:

Asthenia (weakness)
Malignant neoplasm progression (cancer tumour came back)
Pyrexia (fever)
Thrombocytopenia (decrease of platelets in blood)
Hypersensitivity
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)

50-59:

n/a

60+:

Hypotension (abnormally low blood pressure)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)

What are the existing conditions these people have? *

Anaemia (lack of blood): 3 people, 27.27%
Ascites (accumulation of fluid in the abdominal cavity): 3 people, 27.27%
Cardiac Failure: 3 people, 27.27%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3 people, 27.27%
Fever: 2 people, 18.18%
Neuropathy Peripheral (surface nerve damage): 2 people, 18.18%
High Blood Pressure: 2 people, 18.18%
Cough: 2 people, 18.18%
Heart Attack: 2 people, 18.18%
Headache (pain in head): 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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