Cobamamide and Lactulose drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cobamamide (dibencozide) and Lactulose (lactulose). Common drug interactions include asthenia among females and alanine aminotransferase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Cobamamide and Lactulose. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Cobamamide?

Cobamamide has active ingredients of dibencozide. eHealthMe is studying from 1,046 Cobamamide users. Check the latest studies of Cobamamide.

What is Lactulose?

Lactulose has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 46,960 Lactulose users. Check the latest studies of Lactulose.

On Jul, 11, 2026

46 people who take Cobamamide and Lactulose together, and have interactions are studied.

Cobamamide and Lactulose drug interactions.

What are the common drug interactions of Cobamamide and Lactulose, by gender? *:

female:

Asthenia (weakness)
Blood magnesium decreased
Cardiac amyloidosis (protein deposition in heart)
Dementia (madness)
Depression
Diarrhoea
Hypokalaemia (low potassium)
Oedema peripheral (superficial swelling)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

male:

Alanine aminotransferase increased
Blood alkaline phosphatase increased
Thoracic vertebral fracture
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Hepatocellular injury (liver injury)
Febrile neutropenia (fever with reduced white blood cells)
Pulmonary embolism (blockage of the main artery of the lung)
Urinary tract infection
Infection

What are the common drug interactions of Cobamamide and Lactulose, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Arthralgia (joint pain)
Asthenia (weakness)
Drug level decreased
Fistula (an abnormal connection or passageway between two)
Hypotension (abnormally low blood pressure)
Weight increased
Abdominal distension
Anaemia (lack of blood)
Bilirubin conjugated increased
Blood glucose increased

50-59:

Abdominal distension
Liver disorder (liver diseases)
Lung infection
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Thoracic vertebral fracture

60+:

Blood magnesium decreased
Cardiac amyloidosis (protein deposition in heart)
Asthenia (weakness)
Blood pressure increased
Decreased appetite
Confusional state
Mania (a state of abnormally elevated or irritable mood)
Plasma cell myeloma (cancer that begins in plasma cells)
Blood alkaline phosphatase increased
Alanine aminotransferase increased

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 19 people, 41.30%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 11 people, 23.91%
High Blood Pressure: 6 people, 13.04%
Wound Necrosis (damaged cell of wound): 5 people, 10.87%
Dyslipidaemia (abnormal amount of lipids): 5 people, 10.87%
Wound Infection: 4 people, 8.70%
Urination - Excessive Volume: 4 people, 8.70%
Pain: 4 people, 8.70%
Nausea And Vomiting: 3 people, 6.52%
Methylmalonic Aciduria (a disorder, passed down through families, in which the body cannot break down certain proteins and fats and result acid in urine): 3 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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