Codeine sulfate and Ambien drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Codeine sulfate (codeine sulfate) and Ambien (zolpidem tartrate). Common drug interactions include tachycardia among females and cough among males.

The phase IV clinical study analyzes what interactions people have when they take Codeine sulfate and Ambien. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Codeine sulfate?

Codeine sulfate has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 4,510 Codeine sulfate users. Check the latest studies of Codeine sulfate.

What is Ambien?

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 93,519 Ambien users. Check the latest studies of Ambien.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

49 people who take Codeine sulfate and Ambien together, and have interactions are studied.

Codeine sulfate and Ambien drug interactions.

What are the common drug interactions of Codeine Sulfate and Ambien, by gender? *:

female:

Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Blood cholesterol increased
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Emotional distress
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)
Neoplasm malignant (cancer tumour)
Neoplasm progression (growth of tumour)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)

male:

Cough
Depression
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Stomatitis (inflammation of mucous membrane of mouth)
Abdominal discomfort
Abdominal pain
Acne (skin problems that cause pimples)
Activities of daily living impaired
Acute hepatic failure
Aggression

What are the common drug interactions of Codeine Sulfate and Ambien, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Depression
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Hypermobility syndrome (abnormalities cause abnormal stress on a joint or many joint)
Muscle spasms (muscle contraction)
Surgery
Suicide attempt
Cough
Acute hepatic failure
Arthralgia (joint pain)
Asthenia (weakness)

40-49:

Abdominal discomfort
Activities of daily living impaired
Agoraphobia (extreme or irrational fear of crowded spaces or enclosed public places)
Asthenia (weakness)
Avulsion fracture (bone fracture)
Blood urea increased
Chest pain
Colonic polyp (extra part of colon tissue grow in intestine)
Depression
Drug dependence

50-59:

Diarrhoea
Dizziness
Dyspnoea (difficult or laboured respiration)
Enterocele (hernia of the intestine through the vagina)
Facial pain
Fall
Febrile neutropenia (fever with reduced white blood cells)
Gastroenteritis clostridial (inflammation of stomach and intestine clostridial)
Head injury
Hepatomegaly (abnormal enlargement of the liver)

60+:

Pain in extremity
Actinomycosis (infection that causes sores, or abscesses)
Emotional distress
Face oedema (swelling of face)
Gingival swelling (gums swelling)
Hyperplasia (enlargement of an organ or tissue)
Hypoaesthesia (reduced sense of touch or sensation)
Impaired healing
Inflammation
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)

What are the existing conditions these people have? *

Stress And Anxiety: 13 people, 26.53%
Metastases To Bone (cancer spreads to bone): 10 people, 20.41%
Breast Cancer: 10 people, 20.41%
Depression: 9 people, 18.37%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 16.33%
Metastases To Spine (cancer spreads to spine): 5 people, 10.20%
Sleep Disorder: 4 people, 8.16%
Renal Cell Carcinoma (a kidney cancer): 4 people, 8.16%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 8.16%
Bone Pain: 4 people, 8.16%

* Approximation only. Some reports may have incomplete information.

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