Codeine and Dhc plus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Codeine (codeine sulfate) and Dhc plus (acetaminophen; caffeine; dihydrocodeine bitartrate). Common drug interactions include drug dependence among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Codeine and Dhc plus. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

What is Dhc plus?

Dhc plus has active ingredients of acetaminophen; caffeine; dihydrocodeine bitartrate. It is often used in pain. eHealthMe is studying from 1,390 Dhc plus users. Check the latest studies of Dhc plus.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

13 people who take Codeine and Dhc plus together, and have interactions are studied.

What are the common drug interactions of Codeine and Dhc Plus, by gender? *:

female:

Drug dependence
Depression
Emotional distress
Overdose
Death
Disability
Drug abuse
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
General physical condition
Injury

male:

Drug dependence
Depression
Impaired work ability
Learning disability (difficulty in learning)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Road traffic accident
Disability
Emotional distress
Overdose
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

What are the common drug interactions of Codeine and Dhc Plus, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anxiety
Dental caries
Depression
Disturbance in attention
Drug dependence
Learning disability (difficulty in learning)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
Tooth loss

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Migraine (headache): 1 person, 7.69%
Accident: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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