Codeine and Ispaghula drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Codeine (codeine sulfate) and Ispaghula (blond psyllium). Common drug interactions include colitis ischaemic among females and peripheral swelling among males.

The phase IV clinical study analyzes what interactions people have when they take Codeine and Ispaghula. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

What is Ispaghula?

Ispaghula has active ingredients of blond psyllium. eHealthMe is studying from 737 Ispaghula users. Check the latest studies of Ispaghula.

On Aug, 11, 2026

14 people who take Codeine and Ispaghula together, and have interactions are studied.

Codeine and Ispaghula drug interactions.

What are the common drug interactions of Codeine and Ispaghula, by gender? *:

female:

Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Dehydration (dryness resulting from the removal of water)
Fear of eating
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Joint effusion (presence of extra fluid in joint covering)
Ligament rupture (tear in ligament)
Loss of consciousness

male:

Peripheral swelling
Death

What are the common drug interactions of Codeine and Ispaghula, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Diarrhoea
Vomiting

30-39:

Neutropenia (an abnormally low number of neutrophils)
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
White blood cell count decreased

40-49:

n/a

50-59:

Dehydration (dryness resulting from the removal of water)
Fear of eating
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Hypertension (high blood pressure)
Joint effusion (presence of extra fluid in joint covering)
Ligament rupture (tear in ligament)
Loss of consciousness
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Oedema (fluid collection in tissue)

60+:

Bradycardia (abnormally slow heart action)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Electrocardiogram qt prolonged
Syncope (loss of consciousness with an inability to maintain postural tone)
Peripheral swelling
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Death
Hypotension (abnormally low blood pressure)

What are the existing conditions these people have? *

Small Cell Lung Cancer Extensive Stage (small cell lung cancer that has spread (metastasized) to other regions of the body such as another lobe of the lung or the brain): 3 people, 21.43%
Tonsillitis (inflammation of tonsil): 2 people, 14.29%
Constipation: 2 people, 14.29%
Weight Loss: 1 person, 7.14%
Type 2 Diabetes: 1 person, 7.14%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 7.14%
Muscle Spasms (muscle contraction): 1 person, 7.14%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 7.14%
Breast Cancer: 1 person, 7.14%
Borderline Personality Disorder: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and Ispaghula?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously