Codeine and Magnesium hydroxide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Codeine (codeine sulfate) and Magnesium hydroxide (magnesium). Common drug interactions include joint swelling among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Codeine and Magnesium hydroxide. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

What is Magnesium hydroxide?

Magnesium hydroxide has active ingredients of magnesium. eHealthMe is studying from 1,806 Magnesium hydroxide users. Check the latest studies of Magnesium hydroxide.



On Jul, 05, 2026

20 people who take Codeine and Magnesium hydroxide together, and have interactions are studied.

Codeine and Magnesium hydroxide drug interactions.

What are the common drug interactions of Codeine and Magnesium Hydroxide, by gender? *:

female:

  1. Joint swelling
  2. Rash
  3. Fatigue (feeling of tiredness)
  4. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  5. Abdominal pain upper
  6. Alopecia (absence of hair from areas of the body)
  7. Arthralgia (joint pain)
  8. Arthropathy
  9. Hypertension (high blood pressure)
  10. Malaise (a feeling of general discomfort or uneasiness)

male:

  1. Dyspnoea (difficult or laboured respiration)
  2. Respiratory distress (difficulty in breathing)
  3. Pneumonia
  4. Rash pustular (redness with pustules)
  5. Upper respiratory tract infection
  6. Escherichia test positive
  7. Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
  8. Pyrexia (fever)
  9. Sepsis (a severe blood infection that can lead to organ failure and death)
  10. Diarrhoea

What are the common drug interactions of Codeine and Magnesium Hydroxide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Dry mouth
  2. Duodenal ulcer perforation (untreated ulcer can burn through the wall of the stomach)
  3. Fatigue (feeling of tiredness)
  4. Febrile neutropenia (fever with reduced white blood cells)
  5. Fibromyalgia (a long-term condition which causes pain all over the body)
  6. Folliculitis (infection of hair root)
  7. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  8. General physical health deterioration (weak health status)
  9. Glossodynia (a burning or painful sensation in the tongue)
  10. Hand deformity

50-59:

  1. Abdominal pain
  2. Febrile neutropenia (fever with reduced white blood cells)
  3. Drug hypersensitivity
  4. Haematotoxicity (toxins that destroy red blood cells)
  5. Hypersensitivity

60+:

  1. Malaise (a feeling of general discomfort or uneasiness)
  2. Diarrhoea
  3. Blood immunoglobulin a decreased
  4. Blood immunoglobulin g increased
  5. Blood immunoglobulin m increased
  6. Blood pressure increased
  7. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  8. C-reactive protein increased
  9. Cataract (clouding of the lens inside the eye)
  10. Colitis microscopic (inflammation of colon with diarrhoea and abdominal cramps)

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 30.00%
  2. Diabetes: 3 people, 15.00%
  3. Heart Palpitations (feelings or sensations that your heart is pounding or racing): 3 people, 15.00%
  4. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 15.00%
  5. Indigestion: 3 people, 15.00%
  6. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 10.00%
  7. Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 2 people, 10.00%
  8. Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 2 people, 10.00%
  9. High Blood Cholesterol: 2 people, 10.00%
  10. Psoriasis (immune-mediated disease that affects the skin): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and Magnesium hydroxide?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Codeine and Magnesium hydroxide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Magnesium hydroxide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Codeine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Magnesium hydroxide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate and magnesium (the active ingredients of Codeine and Magnesium hydroxide, respectively), and Codeine and Magnesium hydroxide (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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