Codeine and Melphalan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Codeine (codeine sulfate) and Melphalan (melphalan). Common drug interactions include gastrointestinal haemorrhage among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Codeine and Melphalan. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

What is Melphalan?

Melphalan has active ingredients of melphalan. eHealthMe is studying from 20,052 Melphalan users. Check the latest studies of Melphalan.

On Jul, 15, 2026

37 people who take Codeine and Melphalan together, and have interactions are studied.

Codeine and Melphalan drug interactions.

What are the common drug interactions of Codeine and Melphalan, by gender? *:

female:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gingival swelling (gums swelling)
Glomerular filtration rate decreased
Gout (uric acid crystals building up in the body)
Groin pain
Haematoma (collection of blood outside the blood vessels)
Haemoglobin decreased
Heart rate irregular
Hepatomegaly (abnormal enlargement of the liver)
Hip fracture

male:

Febrile neutropenia (fever with reduced white blood cells)
Klebsiella bacteraemia (klebsiella bacteria in blood after infection to lungs)
Acute respiratory failure
Central venous pressure increased
Death
Dyspnoea (difficult or laboured respiration)
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hypertension (high blood pressure)
Immunosuppressant drug level increased

What are the common drug interactions of Codeine and Melphalan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Abdominal pain
Abscess neck (neck abscesses)
Abscess oral (abscess in the mouth)
Acute respiratory failure
Addison's disease (addison's disease, a hormonal disorder disease)
Adrenal haemorrhage (bleeding into the adrenal gland)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety

50-59:

Febrile neutropenia (fever with reduced white blood cells)
Pyrexia (fever)
Death

60+:

Constipation
Lower respiratory tract infection
Spinal column stenosis (narrowing of spinal column)
Upper respiratory tract infection
Thrombocytopenia (decrease of platelets in blood)
Febrile neutropenia (fever with reduced white blood cells)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Herpes zoster
Klebsiella bacteraemia (klebsiella bacteria in blood after infection to lungs)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 25 people, 67.57%
High Blood Pressure: 18 people, 48.65%
Constipation: 16 people, 43.24%
Back Pain: 14 people, 37.84%
Lower Respiratory Tract Infection: 13 people, 35.14%
Nausea (feeling of having an urge to vomit): 13 people, 35.14%
Type 2 Diabetes: 13 people, 35.14%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 12 people, 32.43%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 12 people, 32.43%
Indigestion: 11 people, 29.73%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and Melphalan?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously