Codeine and Naltrexone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Codeine (codeine sulfate) and Naltrexone (naltrexone). Common drug interactions include sciatica among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Codeine and Naltrexone. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

What is Naltrexone?

Naltrexone has active ingredients of naltrexone. eHealthMe is studying from 4,833 Naltrexone users. Check the latest studies of Naltrexone.

On Jul, 17, 2026

20 people who take Codeine and Naltrexone together, and have interactions are studied.

Codeine and Naltrexone drug interactions.

What are the common drug interactions of Codeine and Naltrexone, by gender? *:

female:

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Loss of consciousness
Malaise (a feeling of general discomfort or uneasiness)
Beta haemolytic streptococcal infection (infection with streptococcus pyogenes, a beta-haemolytic bacterium cause mild to moderately severe respiratory tract, skin, and soft tissue)
Necrosis ischaemic (death of cell due to lack of blood supply)
Pneumonia streptococcal (pneumonia, caused by streptococcus pneumoniae)
Septic shock (shock due to blood infection)
Anxiety
Depression
Dizziness

male:

Drug dependence
Abdominal pain
Inflammatory bowel disease
Palpitations (feelings or sensations that your heart is pounding or racing)
Physical disability
Sensory loss (senses loss)
Tremor (trembling or shaking movements in one or more parts of your body)
Completed suicide (act of taking one's own life)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anal haemorrhage

What are the common drug interactions of Codeine and Naltrexone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Completed suicide (act of taking one's own life)
Drug dependence

30-39:

Beta haemolytic streptococcal infection (infection with streptococcus pyogenes, a beta-haemolytic bacterium cause mild to moderately severe respiratory tract, skin, and soft tissue)
Loss of consciousness
Necrosis ischaemic (death of cell due to lack of blood supply)
Pneumonia streptococcal (pneumonia, caused by streptococcus pneumoniae)
Septic shock (shock due to blood infection)

40-49:

n/a

50-59:

Abdominal pain
Abdominal pain upper
Agitation (state of anxiety or nervous excitement)
Anxiety
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cystitis (inflammation of the wall of the bladder)
Depression
Diarrhoea
Dizziness
Fatigue (feeling of tiredness)

60+:

Loss of consciousness
Malaise (a feeling of general discomfort or uneasiness)
Asthenia (weakness)
Breast disorder
Breast mass
Cardiac disorder
Crying
Depression
Dizziness
Dry mouth

What are the existing conditions these people have? *

Cough: 5 people, 25.00%
Vision Blurred: 4 people, 20.00%
Malaise (a feeling of general discomfort or uneasiness): 4 people, 20.00%
Abdominal Pain Upper: 4 people, 20.00%
Blood Pressure Abnormal: 4 people, 20.00%
Depression: 4 people, 20.00%
Diarrhea: 4 people, 20.00%
Fatigue (feeling of tiredness): 4 people, 20.00%
Fluid Retention (an abnormal accumulation of fluid in the blood): 4 people, 20.00%
Hallucinations (sensations that appear real but are created by your mind): 4 people, 20.00%

* Approximation only. Some reports may have incomplete information.

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