Codeine and Senna alexandrina drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Codeine (codeine sulfate) and Senna alexandrina (senna). Common drug interactions include lower respiratory tract infection among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Codeine and Senna alexandrina. It is created by eHealthMe based on reports of 76 people who take the same drugs from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

What is Senna alexandrina?

Senna alexandrina has active ingredients of senna. eHealthMe is studying from 2,853 Senna alexandrina users. Check the latest studies of Senna alexandrina.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

76 people who take Codeine and Senna alexandrina together, and have interactions are studied.

Codeine and Senna alexandrina drug interactions.

What are the common drug interactions of Codeine and Senna Alexandrina, by gender? *:

female:

Lower respiratory tract infection
Oral mucosal discolouration (change in colour of mucous membrane of mouth)
Peripheral swelling
Pulmonary embolism (blockage of the main artery of the lung)
Rhinorrhoea (watery mucus discharge from the nose)
Viral infection
Decreased immune responsiveness
Constipation
Headache (pain in head)
Fatigue (feeling of tiredness)

male:

Dizziness
Hypovolaemia (a decreased volume of circulating blood in the body)
Hypophagia (reduced food intake)
Hypotension (abnormally low blood pressure)
Oral candidiasis (fungal infection of mouth)
Oropharyngeal pain
Stomatitis (inflammation of mucous membrane of mouth)
Syncope (loss of consciousness with an inability to maintain postural tone)
Transplant rejection (a transplant material is not worked)
Blood calcium decreased

What are the common drug interactions of Codeine and Senna Alexandrina, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Constipation
Fatigue (feeling of tiredness)
Headache (pain in head)
Hepatic enzyme increased
Rash erythematous (redness of the skin)
Abdominal pain
Abdominal pain upper
Alanine aminotransferase increased
Anaemia (lack of blood)
Anxiety

40-49:

Abdominal pain
Arthralgia (joint pain)
Constipation
Decreased appetite
Dysgeusia (disorder of the sense of taste)
Epistaxis (bleed from the nose)
Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Glossodynia (a burning or painful sensation in the tongue)
Headache (pain in head)

50-59:

Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Temperature regulation disorder (body is unable to maintain temperature)
Thrombocytopenia (decrease of platelets in blood)
Upper respiratory tract infection
Hypertension (high blood pressure)
Overdose
Abdominal pain
Alopecia (absence of hair from areas of the body)
Chest pain
Cough

60+:

Dizziness
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Haemoglobin decreased
Oral mucosal discolouration (change in colour of mucous membrane of mouth)
Platelet count decreased
Red cell distribution width increased
Syncope (loss of consciousness with an inability to maintain postural tone)
Fall
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hypertension (high blood pressure)

What are the existing conditions these people have? *

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 37 people, 48.68%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 35 people, 46.05%
Herpes Zoster: 34 people, 44.74%
Constipation: 9 people, 11.84%
Diarrhea: 9 people, 11.84%
Mucosal Inflammation (infection of mucous membrane): 6 people, 7.89%
Breast Cancer Metastatic: 6 people, 7.89%
Neuralgia (pain in one or more nerves): 6 people, 7.89%
Urinary Tract Infection: 6 people, 7.89%
Cough: 5 people, 6.58%

* Approximation only. Some reports may have incomplete information.

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