Coffee and Hydrochlorothiazide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Coffee (coffee) and Hydrochlorothiazide (hydrochlorothiazide). Common drug interactions include limb discomfort among females and abnormal dreams among males.

The phase IV clinical study analyzes what interactions people have when they take Coffee and Hydrochlorothiazide. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Coffee?

Coffee has active ingredients of coffee. It is often used in weight loss. eHealthMe is studying from 428 Coffee users. Check the latest studies of Coffee.

What is Hydrochlorothiazide?

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 182,195 Hydrochlorothiazide users. Check the latest studies of Hydrochlorothiazide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

15 people who take Coffee and Hydrochlorothiazide together, and have interactions are studied.

Coffee and Hydrochlorothiazide drug interactions.

What are the common drug interactions of Coffee and Hydrochlorothiazide, by gender? *:

female:

Limb discomfort (discomfort in leg)
Visual impairment
Arthropathy
Cartilage injury
Abdominal discomfort
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Bladder disorder
Blood cholesterol increased
Blood magnesium decreased
Blood zinc decreased

male:

Abnormal dreams
Arthralgia (joint pain)
Blood testosterone decreased
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Drug ineffective
Insomnia (sleeplessness)
Memory impairment
Mobility decreased (ability to move is reduced)
Pain

What are the common drug interactions of Coffee and Hydrochlorothiazide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Blood testosterone decreased

60+:

Drug ineffective
Abdominal discomfort
Fatigue (feeling of tiredness)
Femur fracture
Micturition urgency (urgency to pass the urine)
Rash macular (small, flat red spots)
Sleep disorder due to a general medical condition
Abdominal pain
Abdominal pain upper
Abnormal dreams

What are the existing conditions these people have? *

Sleep Disorder: 4 people, 26.67%
Blood Pressure Abnormal: 3 people, 20.00%
Gastric Disorder (disease of stomach): 3 people, 20.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 20.00%
General Physical Health Deterioration (weak health status): 3 people, 20.00%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 3 people, 20.00%
Herpes Virus Infection: 2 people, 13.33%
High Blood Cholesterol: 2 people, 13.33%
Bacterial Infection: 2 people, 13.33%
Bone Disorder: 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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