Cogentin and Janumet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cogentin (benztropine mesylate) and Janumet (metformin hydrochloride; sitagliptin phosphate). Common drug interactions include hepatic enzyme increased among females and renal failure acute among males.

The phase IV clinical study analyzes what interactions people have when they take Cogentin and Janumet. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Cogentin?

Cogentin has active ingredients of benztropine mesylate. It is often used in tardive dyskinesia. eHealthMe is studying from 7,692 Cogentin users. Check the latest studies of Cogentin.

What is Janumet?

Janumet has active ingredients of metformin hydrochloride; sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 25,023 Janumet users. Check the latest studies of Janumet.

On Jul, 09, 2026

17 people who take Cogentin and Janumet together, and have interactions are studied.

What are the common drug interactions of Cogentin and Janumet, by gender? *:

female:

Hepatic enzyme increased
Logorrhoea (excessive, uncontrollable, or incoherent talkativeness)
Screaming (a long loud piercing cry)
Speech disorder
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)
Tourette's disorder (a neurological disorder characterized by repetitive, stereotyped, involuntary movements and vocalizations called tics)

male:

Renal failure acute (rapid kidney dysfunction)
Hyperkalaemia (damage to or disease of the kidney)
Depression
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Snoring
Blood glucose increased
Blood pressure systolic decreased
Electrocardiogram qrs complex prolonged
Fall
Oedema peripheral (superficial swelling)

What are the common drug interactions of Cogentin and Janumet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Depression
Weight increased

40-49:

Sinus congestion (blockage of sinus)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Snoring
Somnolence (a state of near-sleep, a strong desire for sleep)
Suicidal ideation
Varicose vein (veins that have become enlarged and tortuous)
Vomiting
Acne (skin problems that cause pimples)
Anxiety
Arthralgia (joint pain)

50-59:

Renal failure acute (rapid kidney dysfunction)
Hyperkalaemia (damage to or disease of the kidney)
Bradycardia (abnormally slow heart action)
Renal failure (kidney dysfunction)
Asthenia (weakness)
Atrioventricular block first degree (heart block first degree)
Loss of consciousness
Pain
Pallor
Blood glucose increased

60+:

Angioedema (rapid swelling of the dermis)
Arthralgia (joint pain)
Dyspepsia (indigestion)
Dysphagia (a condition in which swallowing is difficult or painful)
Dystonia (abnormal muscle tone)
Ear pain
Facial pain
Fall
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)

What are the existing conditions these people have? *

Type 2 Diabetes: 2 people, 11.76%
Tachyphrenia (abnormally rapid mental activity): 1 person, 5.88%
Sleep Disorder: 1 person, 5.88%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 5.88%
Rashes (redness): 1 person, 5.88%
Psychotic Disorder: 1 person, 5.88%
Pneumonia: 1 person, 5.88%
Oedema (fluid collection in tissue): 1 person, 5.88%
Nausea (feeling of having an urge to vomit): 1 person, 5.88%
Hallucination, Auditory (perceiving sounds without auditory stimulus): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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