Cogentin and Symmetrel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cogentin (benztropine mesylate) and Symmetrel (amantadine hydrochloride). Common drug interactions include back pain among females and gait abnormal among males.

The phase IV clinical study analyzes what interactions people have when they take Cogentin and Symmetrel. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Cogentin?

Cogentin has active ingredients of benztropine mesylate. It is often used in tardive dyskinesia. eHealthMe is studying from 7,692 Cogentin users. Check the latest studies of Cogentin.

What is Symmetrel?

Symmetrel has active ingredients of amantadine hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 3,398 Symmetrel users. Check the latest studies of Symmetrel.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

26 people who take Cogentin and Symmetrel together, and have interactions are studied.

Cogentin and Symmetrel drug interactions.

What are the common drug interactions of Cogentin and Symmetrel, by gender? *:

female:

Back pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cervicitis (inflammation of the uterine cervix)
Chest pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Crush injury (compression of extremities or other parts of the body that causes muscle swelling and/or neurological disturbances)
Delusion (a false belief or opinion)
Diarrhoea
Dizziness

male:

Gait abnormal
Ataxia (loss of full control of bodily movements)
Cerebral oedema (swelling of brain)
Confusion
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Hepatic congestion (liver congestion)
Laceration (tearing of soft body tissue)
Muscle hypertrophy (a term for the growth and increase of the size of muscle cells)
Muscle stiffness
Oedema lower limb (fluid collection in tissue of lower leg)

What are the common drug interactions of Cogentin and Symmetrel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cervicitis (inflammation of the uterine cervix)
Chest pain
Cough
Crush injury (compression of extremities or other parts of the body that causes muscle swelling and/or neurological disturbances)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Dizziness
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hallucination, visual (seeing things that aren't there)

30-39:

Ataxia (loss of full control of bodily movements)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Drug toxicity
Fall
Gait abnormal
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Cardiac disorder
Cerebral oedema (swelling of brain)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Hepatic congestion (liver congestion)

40-49:

Dyspnoea exertional (breathlessness or shortness of breath)
Oedema peripheral (superficial swelling)
Swelling
Adjustment disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Cataract (clouding of the lens inside the eye)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Deafness

50-59:

Type 2 diabetes mellitus
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hyperglycaemia (high blood sugar)
Neutropenia (an abnormally low number of neutrophils)
Vision blurred

60+:

Balance disorder
Gait abnormal
Psychomotor hyperactivity (feelings of extreme restlessness)
Death
Dysarthria (speech disorder)
Eosinophil count decreased
Fatigue (feeling of tiredness)
Haemoglobin decreased
Hypertension (high blood pressure)
Limb discomfort (discomfort in leg)

What are the existing conditions these people have? *

Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 3 people, 11.54%
Irritable Bowel Syndrome: 2 people, 7.69%
High Blood Pressure: 2 people, 7.69%
Depression: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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