Colace and Estraderm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Colace (docusate ) and Estraderm (estradiol). Common drug interactions include oedema peripheral among females and anaemia postoperative among males.

The phase IV clinical study analyzes what interactions people have when they take Colace and Estraderm. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Colace?

Colace has active ingredients of docusate . It is often used in constipation. eHealthMe is studying from 41,841 Colace users. Check the latest studies of Colace.

What is Estraderm?

Estraderm has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 3,441 Estraderm users. Check the latest studies of Estraderm.

On Aug, 02, 2026

17 people who take Colace and Estraderm together, and have interactions are studied.

What are the common drug interactions of Colace and Estraderm, by gender? *:

female:

Oedema peripheral (superficial swelling)
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)
Anxiety
Breast cancer
Fear of disease
Headache (pain in head)
Hypoxia (low oxygen in tissues)
Metastases to lymph nodes (cancer spreads to lymph node)
Nausea (feeling of having an urge to vomit)

male:

Anaemia postoperative
Balance disorder
Platelet count decreased
Fall
Femur fracture
Fracture displacement
Limb asymmetry (consistent task discrepancy between the two lower limbs)
Limb deformity (functional disability of leg)
Lower limb fracture
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

What are the common drug interactions of Colace and Estraderm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Incisional hernia, obstructive (incisional hernia without mention of obstruction or gangrene)
Abdominal discomfort
Abnormal faeces (abnormal stool)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

50-59:

Hypoxia (low oxygen in tissues)
Aortic bruit (unusual sound that blood makes when it rushes past an obstruction in aortic artery)
Arteriosclerosis (thickening and hardening of arteries)
Back pain
Blood triglycerides increased
Breast calcifications (deposits of calcium that can be seen on a mammogram of the breast)
Breast cancer in situ
Breast mass
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Burning sensation

60+:

Anaemia postoperative
Fall
Amblyopia (lazy eye)
Anaemia (lack of blood)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Asthenia (weakness)
Cardiac arrest
Cardioactive drug level above therapeutic
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Flushing (the warm, red condition of human skin)

What are the existing conditions these people have? *

Pulmonary Embolism (blockage of the main artery of the lung): 1 person, 5.88%
Pain: 1 person, 5.88%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.88%
High Blood Pressure: 1 person, 5.88%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 1 person, 5.88%
Depression: 1 person, 5.88%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 5.88%
Acromegaly (body produces too much growth hormone, leading to excess growth of body tissues): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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