Colace and Linaclotide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Colace (docusate ) and Linaclotide (linaclotide). Common drug interactions include migraine among females and oedema peripheral among males.

The phase IV clinical study analyzes what interactions people have when they take Colace and Linaclotide. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Colace?

Colace has active ingredients of docusate . It is often used in constipation. eHealthMe is studying from 41,841 Colace users. Check the latest studies of Colace.

What is Linaclotide?

Linaclotide has active ingredients of linaclotide. eHealthMe is studying from 2,197 Linaclotide users. Check the latest studies of Linaclotide.

On Jul, 24, 2026

31 people who take Colace and Linaclotide together, and have interactions are studied.

Colace and Linaclotide drug interactions.

What are the common drug interactions of Colace and Linaclotide, by gender? *:

female:

Migraine (headache)
Nausea (feeling of having an urge to vomit)
Anxiety
Fatigue (feeling of tiredness)
Urinary tract infection
Headache (pain in head)
Diarrhoea
Drug ineffective
Asthenia (weakness)
Bipolar disorder (mood disorder)

male:

Oedema peripheral (superficial swelling)
Abdominal discomfort
Pneumonia
Pruritus (severe itching of the skin)
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)
Urinary tract infection
Abdominal pain
Diarrhoea
Dyspepsia (indigestion)

What are the common drug interactions of Colace and Linaclotide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cystitis (inflammation of the wall of the bladder)
Depression
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Fatigue (feeling of tiredness)
Hyperlipidaemia (presence of excess lipids in the blood)
Incontinence (lack of moderation or self-control)
Injection site bruising
Injection site haemorrhage (bleeding from injection site)
Injection site inflammation

50-59:

Anxiety
Small intestinal obstruction (blockage in small intestine)
Arthralgia (joint pain)
Aspartate aminotransferase increased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic kidney disease
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Decreased appetite

60+:

Nausea (feeling of having an urge to vomit)
Urinary tract infection
Rash
Abdominal distension
Abdominal pain upper
Acute respiratory failure
Asthenia (weakness)
Cardiac arrest
Chest pain
Chronic left ventricular failure (long lasting functional impairment of left ventricle of heart)

What are the existing conditions these people have? *

Pain: 8 people, 25.81%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 16.13%
Irritable Bowel Syndrome: 4 people, 12.90%
Type 2 Diabetes: 3 people, 9.68%
Oedema (fluid collection in tissue): 3 people, 9.68%
Nausea And Vomiting: 3 people, 9.68%
Nausea (feeling of having an urge to vomit): 3 people, 9.68%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 3 people, 9.68%
High Blood Cholesterol: 3 people, 9.68%
Gingivitis (inflammation of gums): 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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