Colace and Motegrity drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Colace (docusate ) and Motegrity (prucalopride succinate). Common drug interactions include hypersomnia among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Colace and Motegrity. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Colace?

Colace has active ingredients of docusate . It is often used in constipation. eHealthMe is studying from 41,841 Colace users. Check the latest studies of Colace.

What is Motegrity?

Motegrity has active ingredients of prucalopride succinate. eHealthMe is studying from 1,380 Motegrity users. Check the latest studies of Motegrity.

On Jul, 12, 2026

33 people who take Colace and Motegrity together, and have interactions are studied.

What are the common drug interactions of Colace and Motegrity, by gender? *:

female:

Hypersomnia (excessive daytime sleepiness (eds))
Malaise (a feeling of general discomfort or uneasiness)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle spasms (muscle contraction)
Muscle tightness
Muscular weakness (muscle weakness)
Parosmia (distortion of the sense of smell, as in smelling odours that are not present)
Productive cough
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose)
Visual acuity reduced (reduced clearness of vision)

male:

Dyspnoea (difficult or laboured respiration)
Impaired gastric emptying
Device dislocation
Drug ineffective
Dyskinesia (abnormality or impairment of voluntary movement)
Fall
Hallucination (an experience involving the perception of something not present)
Hyposmia (impairment of the sense of smell)
Increased appetite
Injection site haemorrhage (bleeding from injection site)

What are the common drug interactions of Colace and Motegrity, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Back pain
Cat scratch disease (bacterial infection by cat scratch)
Coma (state of unconsciousness lasting more than six hours)
Cyclic vomiting syndrome (prolonged episodes of severe nausea, vomiting)
Drug ineffective
Dyskinesia (abnormality or impairment of voluntary movement)
Hyposmia (impairment of the sense of smell)
Impaired gastric emptying
Increased appetite
Memory impairment

30-39:

Abdominal pain upper
Impaired gastric emptying
Pancreatitis (inflammation of pancreas)

40-49:

Malaise (a feeling of general discomfort or uneasiness)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Adverse event
Blood urine present
Chronic kidney disease
Dizziness
Dyspepsia (indigestion)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Ileus (a painful obstruction of the ileum or other part of the intestine)

50-59:

Abdominal discomfort
Bladder spasm
Burning sensation
Cough
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)
Hypersomnia (excessive daytime sleepiness (eds))
Lethargy (tiredness)
Migraine (headache)

60+:

Diarrhoea
Dizziness
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chest pain
Chronic kidney disease
Confusional state
Cough
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 18.18%
Immunodeficiency: 5 people, 15.15%
Impaired Gastric Emptying: 5 people, 15.15%
Migraine (headache): 5 people, 15.15%
Autonomic Neuropathy (malfunction of the autonomic nervous system (ans)): 5 people, 15.15%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 12.12%
Depression: 4 people, 12.12%
High Blood Cholesterol: 4 people, 12.12%
Muscle Spasms (muscle contraction): 4 people, 12.12%
Irritable Bowel Syndrome: 4 people, 12.12%

* Approximation only. Some reports may have incomplete information.

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