Colace and Salagen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Colace (docusate ) and Salagen (pilocarpine hydrochloride). Common drug interactions include cardiomyopathy among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Colace and Salagen. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Colace?

Colace has active ingredients of docusate . It is often used in constipation. eHealthMe is studying from 41,841 Colace users. Check the latest studies of Colace.

What is Salagen?

Salagen has active ingredients of pilocarpine hydrochloride. It is often used in sjogren syndrome. eHealthMe is studying from 1,966 Salagen users. Check the latest studies of Salagen.

On Jul, 08, 2026

48 people who take Colace and Salagen together, and have interactions are studied.

What are the common drug interactions of Colace and Salagen, by gender? *:

female:

Cardiomyopathy (weakening of the heart muscle)
Cataract (clouding of the lens inside the eye)
Dry eye (lack of adequate tears)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haemangioma (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
Hepatic lesion
Hypercholesterolaemia (high levels of cholesterol in the blood)
Laryngitis (inflammation of the larynx)
Leukopenia (less number of white blood cells in blood)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)

male:

Abdominal pain
Cardiac disorder
Pain in extremity
Procedural site reaction
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Subcutaneous abscess
Subcutaneous haematoma (collection of blood outside the blood vessels on the skin)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Atelectasis (partial or complete collapse of the lung)

What are the common drug interactions of Colace and Salagen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Pancreatic disorder
Type 2 diabetes mellitus

40-49:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Embolic stroke (stroke due to obstruction due to an embolus)
Pain
Cardiac failure
Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Foot amputation (loss of foot)
Gangrene (body tissue dies)
Localised infection (infection at the single location)
Pain in extremity

50-59:

Leukopenia (less number of white blood cells in blood)
Lumbar radiculopathy (radicular pain in the low back and legs)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Metabolic disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues)
Metastases to central nervous system (cancer spreads to central nervous system)
Muscular weakness (muscle weakness)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)

60+:

Plasma cell myeloma (cancer that begins in plasma cells)
Pneumonia
Diabetes insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function)
Drug effect decreased
Gait disturbance
Glycosylated haemoglobin increased
Gram stain positive
Haematuria traumatic (presence of blood in urine)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Head injury

What are the existing conditions these people have? *

Pain: 14 people, 29.17%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 20.83%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 20.83%
Breast Cancer: 9 people, 18.75%
Insomnia (sleeplessness): 5 people, 10.42%
High Blood Pressure: 5 people, 10.42%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 8.33%
Depression: 4 people, 8.33%
Dry Mouth: 4 people, 8.33%
High Blood Cholesterol: 4 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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