Colistimethate and Singulair drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Colistimethate (colistimethate sodium) and Singulair (montelukast sodium). Common drug interactions include infective pulmonary exacerbation of cystic fibrosis among females and cystic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Colistimethate and Singulair. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Colistimethate?

Colistimethate has active ingredients of colistimethate sodium. eHealthMe is studying from 1,502 Colistimethate users. Check the latest studies of Colistimethate.

What is Singulair?

Singulair has active ingredients of montelukast sodium. It is often used in asthma. eHealthMe is studying from 129,752 Singulair users. Check the latest studies of Singulair.



On Aug, 01, 2026

66 people who take Colistimethate and Singulair together, and have interactions are studied.

Colistimethate and Singulair drug interactions.

What are the common drug interactions of Colistimethate and Singulair, by gender? *:

female:

  1. Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
  2. Infection
  3. Cystic fibrosis (disease of the secretary glands)
  4. Dyspnoea (difficult or laboured respiration)
  5. Hospitalisation
  6. Insomnia (sleeplessness)
  7. Respiratory tract infection viral
  8. Abdominal pain upper
  9. Acute sinusitis
  10. Anxiety

male:

  1. Cystic fibrosis (disease of the secretary glands)
  2. Infection
  3. Cough
  4. Dermatitis psoriasiform (large white or silver flakes on the skin)
  5. Drug ineffective
  6. Eosinophilia (eosinophil count in the peripheral blood exceeds)
  7. Fatigue (feeling of tiredness)
  8. Forced expiratory volume decreased (decreased lung expired air volume)
  9. Hospitalisation
  10. Influenza

What are the common drug interactions of Colistimethate and Singulair, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

  1. Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
  2. Infection

10-19:

  1. Infection
  2. Chest pain
  3. Cystic fibrosis (disease of the secretary glands)
  4. Drug ineffective
  5. Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
  6. Multiple-drug resistance
  7. Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
  8. Pulmonary function test decreased
  9. Respiratory disorder (respiratory disease)
  10. Serratia infection (bacterial infection)

20-29:

  1. Cystic fibrosis (disease of the secretary glands)
  2. Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
  3. Hospitalisation
  4. Abdominal pain
  5. Adverse reaction
  6. Cough
  7. Death
  8. Dermatitis psoriasiform (large white or silver flakes on the skin)
  9. Dyspnoea (difficult or laboured respiration)
  10. Influenza

30-39:

  1. Abdominal pain upper
  2. Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
  3. Acute sinusitis
  4. Anxiety
  5. Chest discomfort
  6. Constipation
  7. Drug hypersensitivity
  8. Dysphonia (speech disorder attributable to a disorder of phonation)
  9. Dyspnoea (difficult or laboured respiration)
  10. Dyspnoea exertional (breathlessness or shortness of breath)

40-49:

  1. Cystic fibrosis (disease of the secretary glands)
  2. Pneumonia
  3. Cataract (clouding of the lens inside the eye)
  4. Influenza
  5. Post procedural infection
  6. Sepsis (a severe blood infection that can lead to organ failure and death)
  7. Thyroid cancer

50-59:

  1. Pyrexia (fever)
  2. Respiratory tract congestion (blockage on respiratory system)
  3. Respiratory tract infection
  4. Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
  5. Tendonitis (a condition that causes pain and swelling of tendons)
  6. Arthralgia (joint pain)
  7. Asthenia (weakness)
  8. Cough
  9. Dyspnoea (difficult or laboured respiration)
  10. Fatigue (feeling of tiredness)

60+:

  1. Arrhythmia (irregular heartbeat)
  2. Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
  3. Cardiac disorder

What are the existing conditions these people have? *

  1. Cystic Fibrosis (disease of the secretary glands): 49 people, 74.24%
  2. Pseudomonas Infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 9 people, 13.64%
  3. Cystic Fibrosis Lung (fibrosis with cyst in the lung): 9 people, 13.64%
  4. Allergic Rhinitis: 4 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Colistimethate and Singulair:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Colistimethate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Singulair:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Colistimethate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Singulair and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on colistimethate sodium and montelukast sodium (the active ingredients of Colistimethate and Singulair, respectively), and Colistimethate and Singulair (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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