Combigan and Bumex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Combigan (brimonidine tartrate; timolol maleate) and Bumex (bumetanide). Common drug interactions include fluid overload among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Combigan and Bumex. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Combigan?

Combigan has active ingredients of brimonidine tartrate; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 7,810 Combigan users. Check the latest studies of Combigan.

What is Bumex?

Bumex has active ingredients of bumetanide. It is often used in swelling. eHealthMe is studying from 9,210 Bumex users. Check the latest studies of Bumex.

On Jul, 09, 2026

13 people who take Combigan and Bumex together, and have interactions are studied.

What are the common drug interactions of Combigan and Bumex, by gender? *:

female:

Fluid overload (too much fluid in the blood)
Hallucination (an experience involving the perception of something not present)
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Injury
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Nightmare (unpleasant dream)
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)

male:

Asthenia (weakness)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Muscle spasms (muscle contraction)

What are the common drug interactions of Combigan and Bumex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Pyrexia (fever)
Ascites (accumulation of fluid in the abdominal cavity)
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)
Oropharyngeal pain
Pain
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 23.08%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 23.08%
Parkinson's Disease: 3 people, 23.08%
Pain: 3 people, 23.08%
Cardiac Failure Congestive: 3 people, 23.08%
Nausea (feeling of having an urge to vomit): 3 people, 23.08%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 23.08%
High Blood Cholesterol: 3 people, 23.08%
Hallucinations (sensations that appear real but are created by your mind): 3 people, 23.08%
Dizziness: 3 people, 23.08%

* Approximation only. Some reports may have incomplete information.

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