Combigan and Imdur drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Combigan (brimonidine tartrate; timolol maleate) and Imdur (isosorbide mononitrate). Common drug interactions include acute respiratory failure among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Combigan and Imdur. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Combigan?

Combigan has active ingredients of brimonidine tartrate; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 7,810 Combigan users. Check the latest studies of Combigan.

What is Imdur?

Imdur has active ingredients of isosorbide mononitrate. It is often used in angina. eHealthMe is studying from 17,367 Imdur users. Check the latest studies of Imdur.

On Jul, 13, 2026

19 people who take Combigan and Imdur together, and have interactions are studied.

What are the common drug interactions of Combigan and Imdur, by gender? *:

female:

Acute respiratory failure
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Atelectasis (partial or complete collapse of the lung)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombocytopenia (decrease of platelets in blood)
Cardiac failure congestive
Dizziness

male:

Fatigue (feeling of tiredness)
Hot flush (sudden feelings of heat)
Dehydration (dryness resulting from the removal of water)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Eye haemorrhage (bleeding in the eye)
Eye pruritus (eye itching)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Heart rate decreased
Infection
Lacrimation increased

What are the common drug interactions of Combigan and Imdur, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood pressure decreased
Death
Dehydration (dryness resulting from the removal of water)
Eye haemorrhage (bleeding in the eye)
Eye pruritus (eye itching)
Heart rate decreased
Infection
Lacrimation increased
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain

50-59:

n/a

60+:

Acute respiratory failure
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Fatigue (feeling of tiredness)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Acute left ventricular failure (heart attack)
Angioedema (rapid swelling of the dermis)
Asthenia (weakness)
Basal ganglia haemorrhage (bleeding from blood vessels in an area of the brain responsible for body movements)
Cough
Death

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 31.58%
High Blood Pressure: 5 people, 26.32%
Multiple Myeloma (cancer of the plasma cells): 5 people, 26.32%
Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 4 people, 21.05%
High Blood Cholesterol: 4 people, 21.05%
Insomnia (sleeplessness): 4 people, 21.05%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 3 people, 15.79%
Dry Eyes (lack of adequate tears): 3 people, 15.79%
Incontinence (lack of moderation or self-control): 3 people, 15.79%
Muscle Spasms (muscle contraction): 3 people, 15.79%

* Approximation only. Some reports may have incomplete information.

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