Combivir and Phenergan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Combivir (lamivudine; zidovudine) and Phenergan (promethazine hydrochloride). Common drug interactions include anhedonia among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Combivir and Phenergan. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Combivir?

Combivir has active ingredients of lamivudine; zidovudine. It is often used in hiv infection. eHealthMe is studying from 15,450 Combivir users. Check the latest studies of Combivir.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

On Jul, 30, 2026

52 people who take Combivir and Phenergan together, and have interactions are studied.

Combivir and Phenergan drug interactions.

What are the common drug interactions of Combivir and Phenergan, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Back pain
Clavicle fracture
Emotional distress
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Jaw fracture
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Osteopenia (a condition where bone mineral density is lower than normal)

male:

Emotional distress
Pain
Cardiac murmur (an heart sound in valve abnormality)
Chronic kidney disease
Staphylococcal bacteraemia (a bacterial infection of blood)
Thrombocytopenia neonatal (decrease of platelets in blood in baby less than a month)
Hepatosplenomegaly neonatal (enlargement of both the liver and the spleen in neonatal)
Hyperbilirubinaemia neonatal (excess of bilirubin in the blood in newborn)
Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)
Pulmonary hypertension (increase in blood pressure in the lung artery)

What are the common drug interactions of Combivir and Phenergan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chronic kidney disease
Renal failure (kidney dysfunction)
Death
Decreased activity
Fear
Impaired work ability
Quality of life decreased
Renal injury (kidney injury)
Skeletal injury (bone and supporting muscle injury)
Malignant neoplasm of lacrimal duct (cancer tumour of tear duct)

30-39:

Anxiety
Chronic kidney disease
Emotional distress
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Mobility decreased (ability to move is reduced)
Pain
Renal cyst (kidney cyst)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Atelectasis (partial or complete collapse of the lung)

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Renal failure (kidney dysfunction)
Decreased activity
Renal colic (renal pain)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hyperkalaemia (damage to or disease of the kidney)

50-59:

n/a

60+:

Anaemia (lack of blood)
Beta haemolytic streptococcal infection (infection with streptococcus pyogenes, a beta-haemolytic bacterium cause mild to moderately severe respiratory tract, skin, and soft tissue)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Haemoglobin decreased
Influenza
Nasopharyngitis (inflammation of the nasopharynx)
Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Pneumonia
Staphylococcus test positive
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the existing conditions these people have? *

Hiv Infection: 38 people, 73.08%
Stress And Anxiety: 8 people, 15.38%
High Blood Pressure: 6 people, 11.54%
Epidural Anaesthesia: 6 people, 11.54%
Drug Exposure During Pregnancy: 6 people, 11.54%
Diabetes: 5 people, 9.62%
Procedural Pain: 4 people, 7.69%
Insomnia (sleeplessness): 4 people, 7.69%
Infection: 4 people, 7.69%
High Blood Cholesterol: 4 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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