Combivir and Pyrimethamine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Combivir (lamivudine; zidovudine) and Pyrimethamine (pyrimethamine). Common drug interactions include arthralgia among females and pancytopenia among males.

The phase IV clinical study analyzes what interactions people have when they take Combivir and Pyrimethamine. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Combivir?

Combivir has active ingredients of lamivudine; zidovudine. It is often used in hiv infection. eHealthMe is studying from 15,450 Combivir users. Check the latest studies of Combivir.

What is Pyrimethamine?

Pyrimethamine has active ingredients of pyrimethamine. eHealthMe is studying from 1,514 Pyrimethamine users. Check the latest studies of Pyrimethamine.

On Jul, 23, 2026

50 people who take Combivir and Pyrimethamine together, and have interactions are studied.

Combivir and Pyrimethamine drug interactions.

What are the common drug interactions of Combivir and Pyrimethamine, by gender? *:

female:

Arthralgia (joint pain)
Drug maladministration
Hepatosplenomegaly (enlargement of both the liver and the spleen)
Joint stiffness
Lung disorder (lung disease)
Nausea (feeling of having an urge to vomit)
Sensory disturbance (sense disturbance)
Skin discolouration (change of skin colour)
Splenomegaly (enlargement of spleen)
Toxoplasmosis (a parasitic disease caused by the protozoan toxoplasma gondii)

male:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Cardiac murmur (an heart sound in valve abnormality)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug exposure during pregnancy
Neonatal disorder (disease of neonates)
Pyrexia (fever)
Testicular pain (pain in testes)
Femoral neck fracture (neck of femur bone fracture)
Abdominal pain
Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)

What are the common drug interactions of Combivir and Pyrimethamine, by age (0-1 to 60+)? *:

0-1:

Eye infection toxoplasmal (a germ called toxoplasma can cause infection within the eye)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Hyperreflexia (overactive or over responsive reflexes)
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
Hypertonia neonatal (abnormal increase in muscle tension and a reduced ability of a muscle to stretch in neonatal)
Neonatal disorder (disease of neonates)
Parkinson's disease
Quadriplegia (a four limb paralysis)
Serology positive

2-9:

n/a

10-19:

n/a

20-29:

Cerebral ventricle dilatation (enlargement of ventricle of brain)
Drug exposure during pregnancy

30-39:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pancreatitis (inflammation of pancreas)
Vomiting
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Pyrexia (fever)
Testicular pain (pain in testes)
Abdominal pain
Anaemia (lack of blood)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)

40-49:

Anaemia (lack of blood)
Thrombocytopenia (decrease of platelets in blood)
Femoral neck fracture (neck of femur bone fracture)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Arthralgia (joint pain)
Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Hallucination, visual (seeing things that aren't there)
Hypomania (a mild form of mania, marked by elation and hyperactivity)

50-59:

Diarrhoea
Dyspnoea exertional (breathlessness or shortness of breath)
Erythema (redness of the skin)
Fracture
Osteosclerosis (an elevation in bone density)
Palpitations (feelings or sensations that your heart is pounding or racing)
Skin plaque (red, scaly patches to appear on the skin)
Vomiting
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Akinesia (loss of control of voluntary muscle movements)

60+:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)

What are the existing conditions these people have? *

Hiv Infection: 14 people, 28.00%
Eye Infection Toxoplasmal (a germ called toxoplasma can cause infection within the eye): 4 people, 8.00%
Cerebral Toxoplasmosis (parasitic disease of brain caused by the protozoan toxoplasma gondii): 3 people, 6.00%
Acquired Immunodeficiency Syndrome (disease of the human immune system caused by the human immunodeficiency virus (hiv)): 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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