Cometriq and Protonix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cometriq (cabozantinib s-malate) and Protonix (pantoprazole sodium). Common drug interactions include uterine leiomyoma among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Cometriq and Protonix. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Cometriq?

Cometriq has active ingredients of cabozantinib s-malate. eHealthMe is studying from 2,712 Cometriq users. Check the latest studies of Cometriq.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,659 Protonix users. Check the latest studies of Protonix.

On Aug, 06, 2026

47 people who take Cometriq and Protonix together, and have interactions are studied.

Cometriq and Protonix drug interactions.

What are the common drug interactions of Cometriq and Protonix, by gender? *:

female:

Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Fatigue (feeling of tiredness)
Headache (pain in head)
Tremor (trembling or shaking movements in one or more parts of your body)
Cerebral haemorrhage (bleeding within the brain)
Influenza
Nasopharyngitis (inflammation of the nasopharynx)
Neoplasm (tumour)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sinusitis (inflammation of sinus)

male:

Nausea (feeling of having an urge to vomit)
Malignant neoplasm progression (cancer tumour came back)
Dysphonia (speech disorder attributable to a disorder of phonation)
Pyrexia (fever)
Aphasia (damage to the parts of the brain that control language)
Dry mouth
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)
Oral discomfort (pain or irritation in mouth)
Oral pain

What are the common drug interactions of Cometriq and Protonix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Malignant neoplasm progression (cancer tumour came back)
Pain

50-59:

Abdominal abscess (collection of pus in abdomen)
Alopecia (absence of hair from areas of the body)
Burning sensation
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Colitis (inflammation of colon)
Diarrhoea
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dry throat
Endotracheal intubation complication
Enteritis (inflammation of the small intestine)

60+:

Decreased appetite
Dizziness
Pain in extremity
Abdominal pain upper
Dyspnoea (difficult or laboured respiration)
Activities of daily living impaired
Arthralgia (joint pain)
Asthenia (weakness)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dysgeusia (disorder of the sense of taste)

What are the existing conditions these people have? *

Thyroid Cancer: 19 people, 40.43%
Renal Cell Carcinoma (a kidney cancer): 18 people, 38.30%
Prostate Cancer: 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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