Comtan and Ketoconazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Comtan (entacapone) and Ketoconazole (ketoconazole). Common drug interactions include akinesia among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Comtan and Ketoconazole. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Comtan?

Comtan has active ingredients of entacapone. It is often used in parkinson's disease. eHealthMe is studying from 3,979 Comtan users. Check the latest studies of Comtan.

What is Ketoconazole?

Ketoconazole has active ingredients of ketoconazole. It is often used in fungal infection. eHealthMe is studying from 16,014 Ketoconazole users. Check the latest studies of Ketoconazole.

On Aug, 03, 2026

14 people who take Comtan and Ketoconazole together, and have interactions are studied.

Comtan and Ketoconazole drug interactions.

What are the common drug interactions of Comtan and Ketoconazole, by gender? *:

female:

Akinesia (loss of control of voluntary muscle movements)
C-reactive protein increased
Dyspnoea (difficult or laboured respiration)
Fall
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Psychomotor hyperactivity (feelings of extreme restlessness)
Red blood cell sedimentation rate increased
Suicide attempt
Weight increased
Abnormal behaviour

male:

Dizziness
Drug ineffective
Heart rate decreased
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Nausea (feeling of having an urge to vomit)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Vomiting
Weight decreased
Abdominal discomfort

What are the common drug interactions of Comtan and Ketoconazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abnormal behaviour
Affective disorder (mental disorder)
Akinesia (loss of control of voluntary muscle movements)
Drug dependence
Dyskinesia (abnormality or impairment of voluntary movement)
Dystonia (abnormal muscle tone)
Flight of ideas
Increased appetite
Insomnia (sleeplessness)
Myalgia (muscle pain)

50-59:

Akinesia (loss of control of voluntary muscle movements)
C-reactive protein increased
Dyspnoea (difficult or laboured respiration)
Fall
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Psychomotor hyperactivity (feelings of extreme restlessness)
Red blood cell sedimentation rate increased
Suicide attempt
Weight increased
Abnormal behaviour

60+:

Dizziness
Drug ineffective
Heart rate decreased
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Nausea (feeling of having an urge to vomit)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Vomiting
Weight decreased
Abdominal discomfort
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

What are the existing conditions these people have? *

Dyskinesia (abnormality or impairment of voluntary movement): 2 people, 14.29%
Nausea And Vomiting: 1 person, 7.14%
Hallucinations (sensations that appear real but are created by your mind): 1 person, 7.14%
Delusion (a false belief or opinion): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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