Comtan and Vicodin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Comtan (entacapone) and Vicodin (acetaminophen; hydrocodone bitartrate). Common drug interactions include diarrhoea among females and agitation among males.

The phase IV clinical study analyzes what interactions people have when they take Comtan and Vicodin. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Comtan?

Comtan has active ingredients of entacapone. It is often used in parkinson's disease. eHealthMe is studying from 3,979 Comtan users. Check the latest studies of Comtan.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

On Jul, 31, 2026

17 people who take Comtan and Vicodin together, and have interactions are studied.

What are the common drug interactions of Comtan and Vicodin, by gender? *:

female:

Diarrhoea
Fatigue (feeling of tiredness)
Dry mouth
Dysphonia (speech disorder attributable to a disorder of phonation)
Stress
Anxiety
Bile duct stone
Confusional state
Depression
Emotional distress

male:

Agitation (state of anxiety or nervous excitement)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Cellulitis gangrenous (localized inflammation of the soft or connective tissue with considerable mass of body tissue dies (necrosis))
Chest pain
Confusional state
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Death
Depression
Diabetic coma
Dizziness

What are the common drug interactions of Comtan and Vicodin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Affect lability (emotional incontinence)
Antisocial personality disorder
Bereavement reaction
Cellulitis gangrenous (localized inflammation of the soft or connective tissue with considerable mass of body tissue dies (necrosis))
Chest pain
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dizziness
Dyskinesia (abnormality or impairment of voluntary movement)
Fall

60+:

Agitation (state of anxiety or nervous excitement)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Drug ineffective
Abnormal behaviour
Bile duct stone
Confusional state
Dyskinesia (abnormality or impairment of voluntary movement)
Hyperkinesia (higher than normal levels of potassium in the circulating blood; associated with kidney failure or sometimes with the use of diuretic drugs)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Post-traumatic stress disorder

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 9 people, 52.94%

* Approximation only. Some reports may have incomplete information.

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