Concerta and Botox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Concerta (methylphenidate hydrochloride) and Botox (botulinum toxin type a). Common drug interactions include nausea among females and seizure like phenomena among males.

The phase IV clinical study analyzes what interactions people have when they take Concerta and Botox. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Concerta?

Concerta has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 25,040 Concerta users. Check the latest studies of Concerta.

What is Botox?

Botox has active ingredients of botulinum toxin type a. It is often used in migraine. eHealthMe is studying from 70,513 Botox users. Check the latest studies of Botox.

On Jul, 31, 2026

62 people who take Concerta and Botox together, and have interactions are studied.

What are the common drug interactions of Concerta and Botox, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Drug ineffective
Pain
Headache (pain in head)
Fatigue (feeling of tiredness)
Parasomnia (sleep disorders that involve abnormal and unnatural movements, behaviours, emotions, perceptions)
Muscle spasms (muscle contraction)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Rash
Contusion (a type of hematoma of tissue in which capillaries)

male:

Seizure like phenomena (a variety of medical conditions may produce sudden episodes which have some similarities to epileptic seizures)
Somnolence (a state of near-sleep, a strong desire for sleep)
Pathological gambling
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Anxiety
Drug ineffective
Brain neoplasm (tumour of brain)
Brain neoplasm malignant (brain cancer tumour)
Emotional distress
Hypersexuality

What are the common drug interactions of Concerta and Botox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Visual impairment
Abdominal pain upper
Blepharospasm (any abnormal contraction or twitch of the eyelid)
Increased appetite
Muscle disorder (muscle disease)
Muscle spasms (muscle contraction)
Pain
Parasomnia (sleep disorders that involve abnormal and unnatural movements, behaviours, emotions, perceptions)
Rash

30-39:

Headache (pain in head)
Autism spectrum disorder (developmental disabilities that can cause significant social, communication and behavioural challenges)
Blood pressure diastolic decreased
Body temperature increased
Decreased appetite
Heart rate increased
Hypotension (abnormally low blood pressure)
Infusion related reaction
Malaise (a feeling of general discomfort or uneasiness)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)

40-49:

Influenza
Drug ineffective
Abnormal behaviour
Apnoea (suspension of external breathing)
Dizziness
Enuresis (repeated inability to control urination)
Euphoric mood (excessively happy but may become angry or irritable)
Fatigue (feeling of tiredness)
Myalgia (muscle pain)
Nasal septum deviation (deviated nasal septum)

50-59:

Contusion (a type of hematoma of tissue in which capillaries)
Surgery
Productive cough
Drug ineffective
Injection site bruising
Rhinalgia (pain in the nose)
Eyelid ptosis (falling of the upper or lower eyelid)
Respiratory tract infection
Dehydration (dryness resulting from the removal of water)
Hypertension (high blood pressure)

60+:

Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 36 people, 58.06%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 23 people, 37.10%
Drowsiness: 9 people, 14.52%
Skin Wrinkling (wrinkle on skin): 7 people, 11.29%
Pain: 4 people, 6.45%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 6.45%
Depression: 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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