Concerta and Serevent drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Concerta (methylphenidate hydrochloride) and Serevent (salmeterol xinafoate). Common drug interactions include insomnia among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Concerta and Serevent. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Concerta?

Concerta has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 25,040 Concerta users. Check the latest studies of Concerta.

What is Serevent?

Serevent has active ingredients of salmeterol xinafoate. It is often used in asthma. eHealthMe is studying from 15,586 Serevent users. Check the latest studies of Serevent.

On Jul, 26, 2026

17 people who take Concerta and Serevent together, and have interactions are studied.

Concerta and Serevent drug interactions.

What are the common drug interactions of Concerta and Serevent, by gender? *:

female:

Insomnia (sleeplessness)
Cholestasis of pregnancy (normal flow of bile in the gallbladder is affected by the high amounts of pregnancy hormones)
Lung disorder (lung disease)
Abnormal dreams
Chest discomfort
Constipation
Drug exposure during pregnancy
Drug ineffective
Dyskinesia (abnormality or impairment of voluntary movement)
Dyspepsia (indigestion)

male:

Nausea (feeling of having an urge to vomit)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Nocturia (the need to get up in the night to urinate)
Overdose
Pathological gambling
Polydipsia (excessive thirst)
Rectal bleeding (bleeding from rectum)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tremor (trembling or shaking movements in one or more parts of your body)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

What are the common drug interactions of Concerta and Serevent, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abnormal dreams
Drooling (drop saliva uncontrollably from the mouth)
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Fear
Hallucination (an experience involving the perception of something not present)
Insomnia (sleeplessness)
Nocturia (the need to get up in the night to urinate)
Polydipsia (excessive thirst)
Sleep terror (felling of terror in sleep)

10-19:

Nausea (feeling of having an urge to vomit)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Vasodilatation (widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls)
Asthenia (weakness)
Headache (pain in head)
Overdose

20-29:

Lung disorder (lung disease)
Drug ineffective
Rectal bleeding (bleeding from rectum)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)

30-39:

Insomnia (sleeplessness)
Muscle twitching
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Weight decreased
Chest discomfort
Dyskinesia (abnormality or impairment of voluntary movement)
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)
Hypoaesthesia facial (reduced sense of touch or sensation on face)

40-49:

Constipation
Feeling jittery
Insomnia (sleeplessness)
Menstruation irregular
Somnolence (a state of near-sleep, a strong desire for sleep)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 4 people, 23.53%
Tooth Abscess (pus formation in tooth): 3 people, 17.65%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 2 people, 11.76%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.88%
Depression: 1 person, 5.88%
Dyskinesia (abnormality or impairment of voluntary movement): 1 person, 5.88%
Dysmenorrhea (painful menstruation): 1 person, 5.88%
Eyelid Twitch (spontaneous and uncontrolled spasms of the muscles): 1 person, 5.88%
Fatigue (feeling of tiredness): 1 person, 5.88%
High Blood Cholesterol: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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